Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVR1 | Q04771 | 4/20 | 0.70 |
| ▸ | JAK2 | O60674 | 5/20 | 0.69 |
| ▸ | CDK2 | P24941 | 3/20 | 0.67 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.67 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.67 |
| ▸ | CDK4 | P11802 | 3/20 | 0.65 |
| ▸ | KDR | P35968 | 2/20 | 0.65 |
| ▸ | GSK3B | P49841 | 1/20 | 0.65 |
| ▸ | ABL1 | P00519 | 2/20 | 0.62 |
| ▸ | EGFR | P00533 | 1/20 | 0.62 |
| ▸ | PRKCA | P17252 | 1/20 | 0.62 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.62 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.61 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.61 |
| ▸ | JAK3 | P52333 | 1/20 | 0.60 |
| ▸ | AURKA | O14965 | 1/20 | 0.60 |
| ▸ | BCR | P11274 | 1/20 | 0.59 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.59 |
| ▸ | IKBKB | O14920 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15212479 | 0.90 | JAK2 (0.76) | ACVR1JAK2CDK2CDK4KDR | |
| SCHEMBL29557336 | 0.88 | CDK4 (0.59) | ACVR1JAK2CDK2CCNA2CCNA1 | |
| SCHEMBL10346581 | 0.88 | JAK2 (0.70) | ACVR1JAK2CDK2CDK4KDR | |
| SCHEMBL7476832 | 0.87 | JAK2 (0.72) | ACVR1JAK2CDK2CDK4KDR | |
| SCHEMBL29618397 | 0.87 | CCNA2 (0.65) | ACVR1JAK2CDK2CCNA2CCNA1 | |
| SCHEMBL29618396 | 0.87 | CCNA2 (0.65) | ACVR1JAK2CDK2CCNA2CCNA1 | |
| SCHEMBL21526586 | 0.85 | ACVR1 (0.69) | ACVR1CDK2CDK4KDRGSK3B | |
| SCHEMBL13555628 | 0.84 | JAK2 (0.72) | JAK2CDK2CDK4KDRGSK3B | |
| SCHEMBL660308 | 0.84 | JAK2 (0.69) | JAK2CDK2CDK4KDRGSK3B | |
| SCHEMBL10192774 | 0.84 | JAK2 (0.69) | JAK2CDK2CDK4KDRGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0233461-B2 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 2002-05-29 | — | — | EP | claimed |
| EP-0233461-B1 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 1996-03-20 | — | — | EP | claimed |
| US-4788195-A | TREATING ASTHMA, ALLERGIC DISEASES, INFLAMMATION AND DIABETES IN MAMMALS | AMERICAN CYANAMID COMPANY (US) | 1988-11-29 | — | — | US | claimed |
| EP-1194421-A4 | SELECTIVE NPY (Y5) ANTAGONISTS | SYNAPTIC PHARMA CORP (US) | 2002-09-11 | — | — | EP | disclosed |
| EP-0233461-B2 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 2002-05-29 | — | — | EP | disclosed |
| EP-1194421-A1 | SELECTIVE NPY (Y5) ANTAGONISTS | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 2002-04-10 | — | — | EP | disclosed |
| WO-2001002379-A1 | SELECTIVE NPY (Y5) ANTAGONISTS | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 2001-01-11 | — | — | WO | disclosed |