Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | CCR1 | P32246 | 2/20 | 0.32 |
| ▸ | CCR5 | P51681 | 2/20 | 0.32 |
| ▸ | CCR8 | P51685 | 2/20 | 0.32 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.32 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.32 |
| ▸ | CDK9 | P50750 | 1/20 | 0.32 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.32 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.32 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | CASP6 | P55212 | 1/20 | 0.32 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.32 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.32 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18984758 | 1.00 | PARP1 (0.35) | PARP1ALDH1A1CYP2A6HSD17B10CCR1 | |
| SCHEMBL18984724 | 0.84 | PARP1 (0.47) | PARP1S1PR4 | |
| SCHEMBL29621587 | 0.84 | PARP1 (0.47) | PARP1S1PR4 | |
| SCHEMBL24596414 | 0.81 | CCR1 (0.37) | PARP1ALDH1A1CYP2A6CCR1CCR5 | |
| SCHEMBL29022258 | 0.81 | CCR1 (0.46) | PARP1ALDH1A1CYP2A6CCR1CCR5 | |
| SCHEMBL30056498 | 0.77 | ALDH1A1 (0.36) | ALDH1A1POLBALDH3A1ALDH1A3MEN1 | |
| SCHEMBL15900362 | 0.77 | CCR1 (0.34) | ALDH1A1CCR1CCR5CCR8MAPT | |
| SCHEMBL28378549 | 0.77 | MEN1 (0.32) | PARP1ALDH1A1CCR1CCR5CCR8 | |
| SCHEMBL15908805 | 0.74 | CCR1 (0.61) | PARP1ALDH1A1CCR1CCR5CCR8 | |
| SCHEMBL14862040 | 0.74 | DYRK1A (0.33) | ALDH1A1CCR1CCR5CCR8DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110964011-B | Synthetic method of 8-chloro-1, 7-naphthyridine-3-formaldehyde | 诚达药业股份有限公司 | 2022-06-21 | — | — | CN | claimed |
| CN-110950865-B | Synthetic method of medical intermediate 8-chloro-1, 7-naphthyridine-3-formaldehyde | 诚达药业股份有限公司 | 2022-05-17 | — | — | CN | claimed |
| CN-113365995-B | Immunomodulators, compositions and methods thereof | 贝达药业股份有限公司 | 2025-03-04 | — | — | CN | disclosed |
| CN-114650993-B | PD-1/PD-L1 inhibitor and preparation method and application thereof | 上海华汇拓医药科技有限公司 | 2024-11-26 | — | — | CN | disclosed |
| CN-111936475-B | Immunomodulator, composition and preparation method thereof | 贝达药业股份有限公司 | 2024-05-10 | — | — | CN | disclosed |
| CN-112566900-B | Immunomodulator, composition and preparation method thereof | 贝达药业股份有限公司 | 2024-04-26 | — | — | CN | disclosed |
| CN-116514715-A | Heterocyclic compounds as immunomodulators | 因赛特公司 | 2023-08-01 | — | — | CN | disclosed |
| CN-108699001-B | Heterocyclic compounds as immunomodulators | 因赛特公司 | 2023-04-14 | — | — | CN | disclosed |
| US-20230111910-A1 | PD-1/PD-L1 INHIBITOR, PREPARATION METHOD THEREFOR, AND USE THEREOF | ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD. (CN) | 2023-04-13 | — | — | US | disclosed |
| CN-115611924-A | PD-1/PD-L1 inhibitor and preparation method and application thereof | 上海华汇拓医药科技有限公司 | 2023-01-17 | — | — | CN | disclosed |
| CN-113248492-B | Heterocycle substituted nitrogen-containing six-membered heterocyclic derivative, preparation method and medical application thereof | 上海海雁医药科技有限公司 | 2022-11-08 | — | — | CN | disclosed |
| CN-110964011-B | Synthetic method of 8-chloro-1, 7-naphthyridine-3-formaldehyde | 诚达药业股份有限公司 | 2022-06-21 | — | — | CN | disclosed |
| CN-110964011-B | Synthetic method of 8-chloro-1, 7-naphthyridine-3-formaldehyde | 诚达药业股份有限公司 | 2022-06-21 | — | — | CN | disclosed |
| CN-110964011-B | Synthetic method of 8-chloro-1, 7-naphthyridine-3-formaldehyde | 诚达药业股份有限公司 | 2022-06-21 | — | — | CN | disclosed |
| CN-114650993-A | PD-1/PD-L1 inhibitor and preparation method and application thereof | 上海华汇拓医药科技有限公司 | 2022-06-21 | — | — | CN | disclosed |
| CN-110950865-B | Synthetic method of medical intermediate 8-chloro-1, 7-naphthyridine-3-formaldehyde | 诚达药业股份有限公司 | 2022-05-17 | — | — | CN | disclosed |
| CN-110950865-B | Synthetic method of medical intermediate 8-chloro-1, 7-naphthyridine-3-formaldehyde | 诚达药业股份有限公司 | 2022-05-17 | — | — | CN | disclosed |
| CN-110950865-B | Synthetic method of medical intermediate 8-chloro-1, 7-naphthyridine-3-formaldehyde | 诚达药业股份有限公司 | 2022-05-17 | — | — | CN | disclosed |
| WO-2022099018-A1 | PROCESS OF PREPARING A PD-1/PD-L1 INHIBITOR | INCYTE CORPORATION (US) | 2022-05-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230111910-A1 | PD-1/PD-L1 INHIBITOR, PREPARATION METHOD THEREFOR, AND USE THEREOF | CD274, PDCD1, PDCD1LG2 | PARP1 264/4885ALDH1A1 266/4885CYP2A6 3798/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.