Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 8/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.36 |
| ▸ | CACNB4 | O00305 | 1/20 | 0.36 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.36 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.36 |
| ▸ | CACNG3 | O60359 | 1/20 | 0.36 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.36 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.36 |
| ▸ | CACNB3 | P54284 | 1/20 | 0.36 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.36 |
| ▸ | CACNG7 | P62955 | 1/20 | 0.36 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.36 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.36 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.36 |
| ▸ | CACNG1 | Q06432 | 1/20 | 0.36 |
| ▸ | CACNB2 | Q08289 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29619054 | 0.85 | GPR119 (0.45) | GPR119PDE4BCACNB4CACNA1ACACNA1G | |
| SCHEMBL29619003 | 0.81 | PTPN2 (0.45) | GPR119MAPTLMNAPDE4BSMN1; SMN2 | |
| SCHEMBL1813964 | 0.81 | ALDH1A1 (0.50) | GPR119ALDH1A1MAPTLMNAPDE4B | |
| SCHEMBL31663792 | 0.80 | PIK3CD (0.45) | ALDH1A1MAPTLMNAPDE4BPIK3CD | |
| SCHEMBL4524382 | 0.78 | PDE4B (0.53) | ALDH1A1MAPTLMNAPDE4BCACNB4 | |
| SCHEMBL12002938 | 0.78 | ALDH1A1 (0.49) | ALDH1A1MAPTLMNAPDE4BCACNB4 | |
| SCHEMBL12002916 | 0.78 | GPR119 (0.51) | GPR119ALDH1A1MAPTLMNAPDE4B | |
| SCHEMBL2575871 | 0.78 | PDE4B (0.49) | ALDH1A1MAPTLMNAPDE4BCACNB4 | |
| SCHEMBL30962804 | 0.75 | ALDH1A1 (0.49) | GPR119ALDH1A1MAPTLMNAPDE4B | |
| SCHEMBL30912375 | 0.75 | ALDH1A1 (0.49) | GPR119ALDH1A1MAPTLMNAPDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4236942-A1 | ISOXAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | Arena Pharmaceuticals, Inc. (US) | 2023-09-06 | — | — | EP | disclosed |
| WO-2022093850-A1 | ISOXAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2022-05-05 | — | — | WO | disclosed |