Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP7 | Q93009 | 1/20 | 0.67 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | MEN1 | O00255 | 5/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 2/20 | 0.53 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | FPR1 | P21462 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3706362 | 1.00 | USP7 (0.67) | USP7ALOX15POLBMEN1KMT2A | |
| SCHEMBL3705477 | 0.93 | ALOX15 (0.61) | USP7ALOX15POLBMEN1KMT2A | |
| SCHEMBL16904825 | 0.91 | ALOX15 (0.63) | USP7ALOX15POLBMEN1KMT2A | |
| SCHEMBL3707736 | 0.90 | ALOX15 (0.59) | USP7ALOX15POLBMEN1KMT2A | |
| SCHEMBL6781400 | 0.90 | MEN1 (0.72) | USP7ALOX15POLBMEN1KMT2A | |
| SCHEMBL3714413 | 0.88 | USP7 (0.73) | USP7ALOX15POLBMEN1KMT2A | |
| SCHEMBL15563413 | 0.88 | ALOX15 (0.60) | USP7ALOX15POLBMEN1KMT2A | |
| SCHEMBL3706307 | 0.87 | USP7 (0.69) | USP7ALOX15POLBMEN1KMT2A | |
| SCHEMBL3707498 | 0.86 | USP7 (0.70) | USP7ALOX15POLBMEN1KMT2A | |
| SCHEMBL3705340 | 0.85 | MEN1 (0.78) | USP7ALOX15POLBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220125760-A1 | USE OF USP7 INHIBITORS FOR THE TREATMENT OF ACUTE MYELOID LEUKEMIA (AML) | UNIVERSITÉ PAUL SABATIER TOULOUSE III (FR) | 2022-04-28 | — | — | US | disclosed |