Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PBRM1 | Q86U86 | 15/20 | 0.44 |
| ▸ | SMARCA2 | P51531 | 14/20 | 0.44 |
| ▸ | SMARCA4 | P51532 | 14/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | NR1I2 | O75469 | 9/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 4/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.34 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.34 |
| ▸ | TUBB | P07437 | 1/20 | 0.34 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.34 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.34 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.34 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.34 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.34 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.34 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.34 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.34 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.34 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.34 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24461303 | 0.88 | SMARCA2 (0.45) | PBRM1SMARCA2SMARCA4BRD4NR1I2 | |
| SCHEMBL27040439 | 0.87 | PBRM1 (0.36) | PBRM1SMARCA2SMARCA4BRD4NR1I2 | |
| SCHEMBL29072084 | 0.86 | SMARCA2 (0.49) | PBRM1SMARCA2SMARCA4 | |
| SCHEMBL29619449 | 0.86 | SMARCA2 (0.49) | PBRM1SMARCA2SMARCA4 | |
| SCHEMBL27053152 | 0.85 | PBRM1 (0.38) | PBRM1SMARCA2SMARCA4BRD4NR1I2 | |
| SCHEMBL30552430 | 0.82 | PBRM1 (0.39) | PBRM1SMARCA2SMARCA4BRD4NR1I2 | |
| SCHEMBL30552520 | 0.82 | PBRM1 (0.39) | PBRM1SMARCA2SMARCA4BRD4NR1I2 | |
| SCHEMBL24461256 | 0.82 | PBRM1 (0.39) | PBRM1SMARCA2SMARCA4BRD4NR1I2 | |
| SCHEMBL24461129 | 0.79 | SMARCA2 (0.45) | PBRM1SMARCA2SMARCA4BRD4NR1I2 | |
| SCHEMBL24461456 | 0.78 | PBRM1 (0.46) | PBRM1SMARCA2SMARCA4BRD4NR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116744929-A | Compounds and uses thereof | 福霍恩治疗公司 | 2023-09-12 | — | — | CN | disclosed |
| WO-2022109426-A1 | COMPOUNDS AND USES THEREOF | FOGHORN THERAPEUTICS INC. (US) | 2022-05-27 | — | — | WO | disclosed |