Tryptophan

Tryptophan

SCHEMBL296200

CSCC[C@H](N)C(=O)O.NCCCC[C@H](N)C(=O)OC(=O)[C@@H](N)CC(N)=O.N[C@@H](CO)C(=O)O.N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O.N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O

nearest known ligand 0.49

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 3/20 0.49
KMT2A Q03164 3/20 0.49
KDM4E B2RXH2 2/20 0.49
MAPT P10636 2/20 0.49
LMNA P02545 1/20 0.49
MPO P05164 1/20 0.49
TSHR P16473 1/20 0.49
BLM P54132 1/20 0.49
PMP22 Q01453 1/20 0.49
HIF1A Q16665 1/20 0.49
CTSC P53634 3/20 0.46
MC4R P32245 2/20 0.42
MC5R P33032 1/20 0.42
MC3R P41968 1/20 0.42
TACR1 P25103 2/20 0.40
GHSR Q92847 5/20 0.40
UTS2R Q9UKP6 1/20 0.39
APAF1 O14727 1/20 0.39
POLB P06746 1/20 0.39
RECQL P46063 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Tryptophan SCHEMBL296201 0.94 KMT2A (0.54) MEN1KMT2AKDM4EMAPTLMNA
Tryptophan SCHEMBL7978131 0.87 KMT2A (0.65) MEN1KMT2AKDM4EMAPTLMNA
Dl-Tryptophan SCHEMBL7978129 0.87 KMT2A (0.65) MEN1KMT2AKDM4EMAPTLMNA
Methionine SCHEMBL8860166 0.85 MEN1 (0.49) MEN1KMT2AKDM4EMAPTLMNA
(D)-Serine SCHEMBL14691550 0.84 KDM4E (0.56) MEN1KMT2AKDM4EMAPTLMNA
D-Tryptophan SCHEMBL14690856 0.83 KDM4E (0.53) MEN1KMT2AKDM4EMAPTLMNA
Methionine SCHEMBL6244204 0.82 MEN1 (0.46) MEN1KMT2AKDM4EMAPTLMNA
Tryptophan SCHEMBL5317118 0.82 KMT2A (0.63) MEN1KMT2AKDM4EMAPTLMNA
Tryptophan SCHEMBL14691551 0.81 KDM4E (0.65) MEN1KMT2AKDM4EMAPTLMNA
Tryptophan SCHEMBL8860168 0.81 KMT2A (0.57) MEN1KMT2AKDM4EMAPTLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2463378-B1 Alpha isomaltosylglucosaccharide synthase, process for producing the same and use thereof HAYASHIBARA CO (JP) 2015-12-23 EP disclosed
EP-2463378-A1 Alpha isomaltosylglucosaccharide synthase, process for producing the same and use thereof KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO (JP) 2012-06-13 EP disclosed
EP-1229112-B1 ALPHA-ISOMALTOSYLGLUCOSACCHARIDE SYNTHASE, PROCESS FOR PRODUCING THE SAME AND USE THEREOF HAYASHIBARA BIOCHEM LAB (JP) 2012-03-14 EP disclosed
EP-1284286-B1 ALPHA-ISOMALTOSYLTRANSFERASE, PROCESS FOR PRODUCING THE SAME AND USE THEREOF HAYASHIBARA BIOCHEM LAB (JP) 2011-11-09 EP disclosed
EP-1445325-B1 PROCESSES FOR PRODUCING ISOMALTOSE AND ISOMALTITOL AND USE THEREOF HAYASHIBARA BIOCHEM LAB (JP) 2010-05-26 EP disclosed
EP-1445325-A1 PROCESSES FOR PRODUCING ISOMALTOSE AND ISOMALTITOL AND USE THEREOF Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo (JP) 2004-08-11 EP disclosed
EP-1284286-A1 ALPHA-ISOMALTOSYLTRANSFERASE, PROCESS FOR PRODUCING THE SAME AND USE THEREOF Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo (JP) 2003-02-19 EP disclosed
EP-1229112-A1 ALPHA-ISOMALTOSYLGLUCOSACCHARIDE SYNTHASE, PROCESS FOR PRODUCING THE SAME AND USE THEREOF Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo (JP) 2002-08-07 EP disclosed