Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Tryptophan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | BLM | P54132 | 2/20 | 0.54 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.54 |
| ▸ | MPO | P05164 | 1/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.54 |
| ▸ | CTSC | P53634 | 3/20 | 0.50 |
| ▸ | MC4R | P32245 | 2/20 | 0.46 |
| ▸ | MC5R | P33032 | 1/20 | 0.46 |
| ▸ | MC3R | P41968 | 1/20 | 0.46 |
| ▸ | GHSR | Q92847 | 5/20 | 0.42 |
| ▸ | APAF1 | O14727 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tryptophan SCHEMBL296200 | 0.94 | MEN1 (0.49) | KMT2AKDM4EMAPTMEN1LMNA | |
| Tryptophan SCHEMBL7978131 | 0.91 | KMT2A (0.65) | KMT2AKDM4EMAPTMEN1LMNA | |
| Dl-Tryptophan SCHEMBL7978129 | 0.91 | KMT2A (0.65) | KMT2AKDM4EMAPTMEN1LMNA | |
| Tryptophan SCHEMBL5317118 | 0.88 | KMT2A (0.63) | KMT2AKDM4EMAPTMEN1LMNA | |
| Tryptophan SCHEMBL293836 | 0.86 | MEN1 (0.49) | KMT2AKDM4EMAPTMEN1LMNA | |
| Tryptophan SCHEMBL14691551 | 0.86 | KDM4E (0.65) | KMT2AKDM4EMAPTMEN1LMNA | |
| Tryptophan SCHEMBL8860168 | 0.85 | KMT2A (0.57) | KMT2AKDM4EMAPTMEN1LMNA | |
| Dl-Tryptophan SCHEMBL20857030 | 0.85 | KMT2A (0.57) | KMT2AKDM4EMAPTMEN1LMNA | |
| Dl-Tryptophan SCHEMBL8860161 | 0.85 | KMT2A (0.57) | KMT2AKDM4EMAPTMEN1LMNA | |
| Tryptophan SCHEMBL3442743 | 0.85 | KMT2A (0.61) | KMT2AKDM4EMAPTMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2463378-B1 | Alpha isomaltosylglucosaccharide synthase, process for producing the same and use thereof | HAYASHIBARA CO (JP) | 2015-12-23 | — | — | EP | disclosed |
| EP-2463378-A1 | Alpha isomaltosylglucosaccharide synthase, process for producing the same and use thereof | KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO (JP) | 2012-06-13 | — | — | EP | disclosed |
| EP-1229112-B1 | ALPHA-ISOMALTOSYLGLUCOSACCHARIDE SYNTHASE, PROCESS FOR PRODUCING THE SAME AND USE THEREOF | HAYASHIBARA BIOCHEM LAB (JP) | 2012-03-14 | — | — | EP | disclosed |
| EP-1284286-B1 | ALPHA-ISOMALTOSYLTRANSFERASE, PROCESS FOR PRODUCING THE SAME AND USE THEREOF | HAYASHIBARA BIOCHEM LAB (JP) | 2011-11-09 | — | — | EP | disclosed |
| EP-1445325-B1 | PROCESSES FOR PRODUCING ISOMALTOSE AND ISOMALTITOL AND USE THEREOF | HAYASHIBARA BIOCHEM LAB (JP) | 2010-05-26 | — | — | EP | disclosed |
| EP-1445325-A1 | PROCESSES FOR PRODUCING ISOMALTOSE AND ISOMALTITOL AND USE THEREOF | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo (JP) | 2004-08-11 | — | — | EP | disclosed |
| EP-1284286-A1 | ALPHA-ISOMALTOSYLTRANSFERASE, PROCESS FOR PRODUCING THE SAME AND USE THEREOF | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo (JP) | 2003-02-19 | — | — | EP | disclosed |
| EP-1229112-A1 | ALPHA-ISOMALTOSYLGLUCOSACCHARIDE SYNTHASE, PROCESS FOR PRODUCING THE SAME AND USE THEREOF | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo (JP) | 2002-08-07 | — | — | EP | disclosed |