Bromide

Bromide

SCHEMBL29620202

CC(C)[n+]1cn(Cc2ccccc2)c2ccccc21.[Br-]

nearest known ligand 0.55

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1

The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 3/20 0.45
XDH P47989 1/20 0.43
TNF P01375 1/20 0.38
CYP11B1 P15538 1/20 0.38
CYP11B2 P19099 1/20 0.38
RGS12 O14924 1/20 0.38
CYP2D6 P10635 1/20 0.38
CYP2C19 P33261 1/20 0.38
CTDSP1 Q9GZU7 1/20 0.38
CA2 P00918 1/20 0.37
HTR6 P50406 1/20 0.36
CYP19A1 P11511 1/20 0.36
CA1 P00915 1/20 0.36
CHRNB2 P17787 1/20 0.35
CHRNA7 P36544 1/20 0.35
CHRNA4 P43681 1/20 0.35
SMN1; SMN2 Q16637 2/20 0.35
KCNA3 P22001 1/20 0.35
PDE4A P27815 1/20 0.35
PDE4B Q07343 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24331750 0.98 KMT2A (0.46) KMT2AXDHTNFCYP11B1CYP11B2
Bromide SCHEMBL4384622 0.83 KMT2A (0.33) KMT2AXDHRGS12CYP2D6CYP2C19
Bromide SCHEMBL9328086 0.82 KMT2A (0.35) KMT2AXDHRGS12CYP2D6CYP2C19
SCHEMBL18844450 0.79 CA2 (0.38) KMT2AXDHRGS12CYP2D6CYP2C19
SCHEMBL26921378 0.76 XDH (0.48) KMT2AXDHTNFCYP11B1CYP11B2
Bromide SCHEMBL17024429 0.74 KMT2A (0.43) KMT2AXDHTNFCYP11B1CYP11B2
Bromide SCHEMBL2214307 0.74 XDH (0.60) KMT2AXDHTNFCYP11B1CYP11B2
SCHEMBL15365349 0.73 KMT2A (0.46) KMT2AXDHTNFCYP11B1CYP11B2
Formic Acid SCHEMBL29625053 0.73 KMT2A (0.59) KMT2AXDHTNFCYP11B1CYP11B2
SCHEMBL2218265 0.72 XDH (0.57) KMT2AXDHTNFCYP11B1CYP11B2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022081953-A1 SYNTHESIS OF ALKYNONES VIA CARBONYLATIVE SONOGASHIRA COUPLING REACTIONS CATALYZED BY PD(II)-N-HETEROCYCLIC CARBENE-PYRIDINE COMPLEXES SAUDI ARABIAN OIL COMPANY (SA) 2022-04-21 WO disclosed