Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | IDH1 | O75874 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 2/20 | 0.45 |
| ▸ | NFATC1 | O95644 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15164719 | 0.84 | PKN2 (0.42) | ALDH1A1IDH1PARP1KDM4EHTT | |
| SCHEMBL29620451 | 0.81 | KDM4E (0.40) | KDM4EALOX15NPSR1TSHRSIRT1 | |
| SCHEMBL29620463 | 0.81 | KDM4E (0.43) | SMN1; SMN2PARP1KDM4EALOX15MAPT | |
| SCHEMBL29620459 | 0.80 | IDH1 (0.40) | IDH1KDM4EALOX15NPSR1TSHR | |
| SCHEMBL25225949 | 0.79 | KDM4E (0.59) | ALDH1A1SMN1; SMN2PARP1MAPK1HSD17B10 | |
| SCHEMBL31750354 | 0.76 | IDH1 (0.49) | ALDH1A1IDH1GSK3BMAPK1KDM4E | |
| SCHEMBL11923831 | 0.75 | CYP11B2 (0.41) | PARP1NPSR1 | |
| SCHEMBL2144299 | 0.74 | PARP1 (0.45) | ALDH1A1SMN1; SMN2IDH1PARP1HSD17B10 | |
| SCHEMBL15727820 | 0.74 | PARP1 (0.45) | ALDH1A1SMN1; SMN2PARP1MAPK1HSD17B10 | |
| SCHEMBL30434602 | 0.74 | PARP1 (0.45) | ALDH1A1SMN1; SMN2IDH1PARP1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114555597-B | Isocitrate Dehydrogenase (IDH) inhibitors | 浙江迈同生物医药有限公司 | 2024-06-04 | — | — | CN | claimed |
| EP-4041732-A1 | ISO-CITRATE DEHYDROGENASE (IDH) INHIBITOR | ZHEJIANG METON PHARMACEUTICAL CO., LTD (CN) | 2022-08-17 | — | — | EP | claimed |
| CN-114555597-A | Isocitrate Dehydrogenase (IDH) inhibitors | 浙江迈同生物医药有限公司 | 2022-05-27 | — | — | CN | claimed |
| US-12441725-B2 | ISO-citrate dehydrogenase (IDH) inhibitor | ZHEJIANG METON PHARMACEUTICAL CO., LTD (CN) | 2025-10-14 | — | — | US | disclosed |
| US-20240116917-A1 | ISO-CITRATE DEHYDROGENASE (IDH) INHIBITOR | ZHEJIANG METON PHARMACEUTICAL CO., LTD (CN) | 2024-04-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240116917-A1 | ISO-CITRATE DEHYDROGENASE (IDH) INHIBITOR | IDH2, IDH3A, IDH1 | ALDH1A1 538/4885SMN1; SMN2 3453/4885IDH1 3/4885 |
| US-12441725-B2 | ISO-citrate dehydrogenase (IDH) inhibitor | IDH2, IDH3A, IDH1 | ALDH1A1 538/4885SMN1; SMN2 3453/4885IDH1 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.