Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.40 |
| ▸ | USP19 | O94966 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.35 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 2/20 | 0.35 |
| ▸ | DRD2 | P14416 | 2/20 | 0.35 |
| ▸ | DRD5 | P21918 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | DHPS | P49366 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15164719 | 0.84 | PKN2 (0.42) | KDM4EALOX15TSHRSIRT1USP19 | |
| SCHEMBL29620463 | 0.84 | KDM4E (0.43) | KDM4EALOX15TSHRSIRT1USP19 | |
| SCHEMBL29620459 | 0.81 | IDH1 (0.40) | KDM4EALOX15TSHRSIRT1USP19 | |
| SCHEMBL29620469 | 0.81 | ALDH1A1 (0.49) | KDM4EALOX15TSHRSIRT1NPSR1 | |
| SCHEMBL29620441 | 0.80 | USP19 (0.42) | KDM4EALOX15TSHRSIRT1USP19 | |
| SCHEMBL29620429 | 0.80 | USP19 (0.39) | KDM4EALOX15TSHRSIRT1USP19 | |
| SCHEMBL30947594 | 0.75 | CYP11B2 (0.41) | KDM4ETSHRUSP19NPSR1CYP11B2 | |
| SCHEMBL11923831 | 0.75 | CYP11B2 (0.41) | NPSR1CYP11B2PDE3BPDE3A | |
| SCHEMBL29620473 | 0.74 | ALOX15 (0.36) | KDM4EALOX15TSHRUSP19NPSR1 | |
| SCHEMBL31667471 | 0.74 | DHPS (0.46) | DHPS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4041732-A1 | ISO-CITRATE DEHYDROGENASE (IDH) INHIBITOR | ZHEJIANG METON PHARMACEUTICAL CO., LTD (CN) | 2022-08-17 | — | — | EP | claimed |
| CN-114555597-A | Isocitrate Dehydrogenase (IDH) inhibitors | 浙江迈同生物医药有限公司 | 2022-05-27 | — | — | CN | claimed |