SCHEMBL29620536

SCHEMBL29620536

c1ccc2cc(-c3ccnc(-c4ccoc4)n3)ccc2c1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DKK1 O94907 3/20 0.47
CYP1A2 P05177 12/20 0.47
MEN1 O00255 8/20 0.47
KMT2A Q03164 8/20 0.47
CYP2D6 P10635 8/20 0.47
CYP2C19 P33261 8/20 0.47
CYP3A4 P08684 7/20 0.47
MAPT P10636 6/20 0.47
USP2 O75604 6/20 0.47
KDM4E B2RXH2 4/20 0.47
TSHR P16473 3/20 0.47
SMN1; SMN2 Q16637 4/20 0.46
NPC1 O15118 1/20 0.46
POLB P06746 1/20 0.46
RAB9A P51151 1/20 0.46
ALDH1A1 P00352 8/20 0.43
HSD17B10 Q99714 7/20 0.43
ALOX15 P16050 5/20 0.43
LMNA P02545 3/20 0.43
TP53 P04637 2/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29620556 0.83 CYP1A2 (0.42) CYP1A2MEN1KMT2ACYP2D6CYP2C19
SCHEMBL18731740 0.82 KMT2A (0.59) DKK1CYP1A2MEN1KMT2ACYP2D6
SCHEMBL14725230 0.79 KMT2A (0.54) DKK1CYP1A2MEN1KMT2ACYP2D6
SCHEMBL29620537 0.79 KMT2A (0.52) CYP1A2MEN1KMT2ACYP2D6CYP2C19
SCHEMBL26260174 0.78 ESR1 (0.50) CYP1A2MEN1KMT2ACYP2C19MAPT
SCHEMBL17876893 0.78 DKK1 (0.48) DKK1CYP1A2MEN1KMT2ACYP2C19
SCHEMBL3651524 0.77 DKK1 (0.48) DKK1CYP1A2MEN1KMT2ACYP2D6
SCHEMBL29739104 0.75 CYP2D6 (0.43) CYP1A2MEN1KMT2ACYP2D6CYP2C19
SCHEMBL3649135 0.75 ADRB2 (0.56) DKK1CYP1A2MEN1KMT2AMAPT
SCHEMBL17876900 0.74 SIRT2 (0.48) DKK1CYP1A2MEN1KMT2AMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114555566-A Organic compound and organic electroluminescent element comprising same 索路思高新材料有限公司 2022-05-27 CN disclosed