Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 2/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.43 |
| ▸ | PGR | P06401 | 3/20 | 0.43 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | CES1 | P23141 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 14/20 | 0.42 |
| ▸ | RAF1 | P04049 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29621942 | 0.81 | MAPK14 (0.44) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL12782405 | 0.78 | MAPK14 (0.50) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL29621846 | 0.78 | MAPK14 (0.50) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL5975963 | 0.77 | PGR (0.49) | PGRMAPK14 | |
| SCHEMBL5975458 | 0.75 | MAPK14 (0.53) | PGRMAPK14RAF1CYP1A2CYP2C9 | |
| SCHEMBL29384453 | 0.75 | MAPK14 (0.53) | PGRMAPK14RAF1CYP1A2CYP2C9 | |
| SCHEMBL1223499 | 0.74 | PGR (0.49) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL16858556 | 0.73 | PGR (0.40) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL5499005 | 0.73 | PGR (0.55) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL22104724 | 0.73 | CYP1A2 (0.55) | PDE4APDE4BPDE4CPDE4DPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4240722-A1 | OXINDOLES AND METHODS OF USE THEREOF | Aligos Therapeutics, Inc. (US) | 2023-09-13 | — | — | EP | disclosed |
| WO-2022099066-A1 | OXINDOLES AND METHODS OF USE THEREOF | ALIGOS THERAPEUTICS, INC. (US) | 2022-05-12 | — | — | WO | disclosed |