Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 11/20 | 0.55 |
| ▸ | PDE4A | P27815 | 2/20 | 0.55 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.55 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.55 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.55 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.55 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1223242 | 0.97 | PGR (0.55) | PGRPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL61843 | 0.95 | PGR (0.56) | PGRPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4296570 | 0.93 | PGR (0.53) | PGRPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL22471385 | 0.87 | PDE4A (0.46) | PGRPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL2214049 | 0.87 | BACE1 (0.50) | PGRPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL2075283 | 0.86 | CMA1 (0.46) | PGRPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL30224398 | 0.86 | CMA1 (0.46) | PGRPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5959179 | 0.85 | EPHX2 (0.59) | PGRPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL30954711 | 0.85 | PGR (0.47) | PGRPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL2255855 | 0.85 | PGR (0.43) | PGRPDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12478621-B2 | Substituted aminoquinolones as dgkalpha inhibitors for immune activation | DEUTSCHES KREBSFORSCHUNGSZENTRUM (DE) | 2025-11-25 | — | — | US | disclosed |
| US-20250325677-A1 | STAT6 DEGRADERS | GILEAD SCIENCES INC (US) | 2025-10-23 | — | — | US | disclosed |
| US-20250320206-A1 | STAT6 DEGRADERS | GILEAD SCIENCES INC (US) | 2025-10-16 | — | — | US | disclosed |
| US-20250304561-A1 | MODULATORS OF THR-BETA AND METHODS OF USE THEREOF | ALIGOS THERAPEUTICS, INC. (US) | 2025-10-02 | — | — | US | disclosed |
| US-12428411-B2 | Preparation of oxindole derivatives as novel diacylglyceride o-acyltransferase 2 inhibitors | MERCK SHARP & DOHME LLC (US) | 2025-09-30 | — | — | US | disclosed |
| US-12410159-B2 | Preparation of oxindole derivatives as novel diacylglyceride O-acyltransferase 2 inhibitors | MERCK SHARP & DOHME LLC (US) | 2025-09-09 | — | — | US | disclosed |
| WO-2025092818-A1 | PYRIDINE DERIVATIVE AND USE THEREOF IN MEDICINE | 康百达（四川）生物医药科技有限公司 | 2025-05-08 | — | — | WO | disclosed |
| EP-4523692-A2 | MODULATORS OF THR-SS AND METHODS OF USE THEREOF | Aligos Therapeutics, Inc. (US) | 2025-03-19 | — | — | EP | disclosed |
| CN-119462695-A | Pyridine derivative and application thereof | 康百达（四川）生物医药科技有限公司 | 2025-02-18 | — | — | CN | disclosed |
| EP-3965884-B1 | MODULATORS OF THR-BETA WITH A DIOXO-1,2,4-TRIAZYL HEAD GROUP | ALIGOS THERAPEUTICS INC (US) | 2025-01-15 | — | — | EP | disclosed |
| EP-3310772-A1 | SPIRO[CYCLOBUTANE-1,3'-INDOLIN]-2'-ONE DERIVATIVES AS BROMODOMAIN INHIBITORS | Orion Corporation (FI) | 2018-04-25 | — | — | EP | disclosed |
| US-9745267-B2 | Compounds as modulators of RORC | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2017-08-29 | — | — | US | disclosed |
| US-9745267-B2 | Compounds as modulators of RORC | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2017-08-29 | — | — | US | disclosed |
| WO-2016203112-A1 | SPIRO[CYCLOBUTANE-1,3'-INDOLIN]-2'-ONE DERIVATIVES AS BROMODOMAIN INHIBITORS | ORION CORPORATION (FI) | 2016-12-22 | — | — | WO | disclosed |
| WO-2016203112-A1 | SPIRO[CYCLOBUTANE-1,3'-INDOLIN]-2'-ONE DERIVATIVES AS BROMODOMAIN INHIBITORS | ORION CORPORATION (FI) | 2016-12-22 | — | — | WO | disclosed |
| US-20160251310-A1 | COMPOUNDS AS MODULATORS OF RORC | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2016-09-01 | — | — | US | disclosed |
| US-20160251310-A1 | COMPOUNDS AS MODULATORS OF RORC | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2016-09-01 | — | — | US | disclosed |
| EP-1778222-A1 | PROGESTERONE RECEPTOR MODULATORS COMPRISING PYRROLE-OXINDOLE DERIVATIVES AND USES THEREOF | Wyeth (US) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006023107-A1 | PROGESTERONE RECEPTOR MODULATORS COMPRISING PYRROLE-OXINDOLE DERIVATIVES AND USES THEREOF | WYETH (US) | 2006-03-02 | — | — | WO | disclosed |
| US-20060030615-A1 | Progesterone receptor modulators comprising pyrrole-oxindole derivatives and uses thereof | WYETH (US) | 2006-02-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250304561-A1 | MODULATORS OF THR-BETA AND METHODS OF USE THEREOF | THRB, THRA, TRHR | PGR 820/4885PDE4A 1527/4885PDE4B 1292/4885 |
| US-20250325677-A1 | STAT6 DEGRADERS | STAT6, STAT5B, STAT1 | PGR 1299/4885PDE4A 757/4885PDE4B 985/4885 |
| US-12478621-B2 | Substituted aminoquinolones as dgkalpha inhibitors for immune activation | DGKK, DGKG, DGKA | PGR 3500/4885PDE4A 114/4885PDE4B 92/4885 |
| US-12410159-B2 | Preparation of oxindole derivatives as novel diacylglyceride O-acyltransferase 2 inhibitors | DGAT2, DGAT1, MOGAT2 | PGR 2417/4885PDE4A 1509/4885PDE4B 1165/4885 |
| US-12428411-B2 | Preparation of oxindole derivatives as novel diacylglyceride o-acyltransferase 2 inhibitors | DGAT2, DGAT1, MOGAT2 | PGR 2417/4885PDE4A 1509/4885PDE4B 1165/4885 |
| US-20160251310-A1 | COMPOUNDS AS MODULATORS OF RORC | RORC, RORB, RORA | PGR 704/4885PDE4A 535/4885PDE4B 566/4885 |
| US-20060030615-A1 | Progesterone receptor modulators comprising pyrrole-oxindole derivatives and uses thereof | PGR, PGRMC2, PGRMC1 | PGR 1/4885PDE4A 1211/4885PDE4B 1656/4885 |
| US-20250320206-A1 | STAT6 DEGRADERS | STAT6, STAT5B, STAT1 | PGR 1299/4885PDE4A 757/4885PDE4B 985/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.