Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | PDK1 | Q15118 | 4/20 | 0.44 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.43 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CTSL | P07711 | 1/20 | 0.40 |
| ▸ | CTSB | P07858 | 1/20 | 0.40 |
| ▸ | CTSS | P25774 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | TGM2 | P21980 | 1/20 | 0.40 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29622084 | 0.86 | HTT (0.42) | HTTSMN1; SMN2LMNAPDK1PDK2 | |
| SCHEMBL29622170 | 0.84 | LMNA (0.40) | HTTSMN1; SMN2LMNAL3MBTL1MAPT | |
| SCHEMBL29622112 | 0.78 | MLLT3 (0.47) | SMN1; SMN2LMNAL3MBTL1MAPT | |
| SCHEMBL29622224 | 0.77 | MLLT3 (0.45) | SMN1; SMN2LMNAL3MBTL1MAPT | |
| SCHEMBL17846625 | 0.77 | LMNA (0.61) | HTTSMN1; SMN2LMNAL3MBTL1MAPT | |
| SCHEMBL10827358 | 0.76 | LMNA (0.60) | HTTSMN1; SMN2LMNAL3MBTL1MAPT | |
| SCHEMBL25983314 | 0.75 | LMNA (0.56) | HTTSMN1; SMN2LMNAL3MBTL1MAPT | |
| SCHEMBL14772158 | 0.74 | LMNA (0.65) | HTTSMN1; SMN2LMNAL3MBTL1MAPT | |
| SCHEMBL19763216 | 0.74 | LMNA (0.65) | HTTSMN1; SMN2LMNAL3MBTL1MAPT | |
| SCHEMBL25962301 | 0.74 | LMNA (0.57) | HTTSMN1; SMN2LMNAL3MBTL1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230391765-A1 | HETEROBIFUNCTIONAL COMPOUNDS AS DEGRADERS OF ENL | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI | 2023-12-07 | — | — | US | disclosed |
| WO-2022086937-A9 | HETEROBIFUNCTIONAL COMPOUNDS AS DEGRADERS OF ENL | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2023-02-02 | — | — | WO | disclosed |
| WO-2022086937-A1 | HETEROBIFUNCTIONAL COMPOUNDS AS DEGRADERS OF ENL | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2022-04-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230391765-A1 | HETEROBIFUNCTIONAL COMPOUNDS AS DEGRADERS OF ENL | MLLT1, BCR, MCL1 | HTT 698/4885SMN1; SMN2 3066/4885LMNA 1659/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.