Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | FBP1 | P09467 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21858009 | 1.00 | MAPT (0.42) | MAPTPOLBHDAC3HDAC4HDAC1 | |
| SCHEMBL25757440 | 0.79 | NOTUM (0.40) | MAPTPOLBHDAC3HDAC1HDAC6 | |
| SCHEMBL21858005 | 0.78 | F2R (0.40) | MAPTPOLBPKMSMN1; SMN2FBP1 | |
| SCHEMBL29622995 | 0.78 | F2R (0.40) | MAPTPOLBPKMSMN1; SMN2FBP1 | |
| SCHEMBL21857985 | 0.76 | F2R (0.41) | MAPTPOLBPKMSMN1; SMN2FBP1 | |
| SCHEMBL15948290 | 0.76 | POLB (0.48) | MAPTPOLBHDAC3HDAC4HDAC1 | |
| SCHEMBL30628314 | 0.74 | MAPT (0.45) | MAPTPOLBHDAC3HDAC4HDAC1 | |
| SCHEMBL17157482 | 0.74 | MAPT (0.45) | MAPTPOLBHDAC3HDAC4HDAC1 | |
| SCHEMBL17420548 | 0.74 | MAPT (0.43) | MAPTPOLBHDAC3HDAC4HDAC1 | |
| SCHEMBL29622932 | 0.73 | FBP1 (0.39) | MAPTPOLBPKMSMN1; SMN2FBP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023070483-A1 | PROCESSES OF MAKING 3-FLUORO-5- ( ( (1R, 2S, 2aS) -1, 2, 3, 3, 4, 4-HEXAFLUORO-2A-HYDROXY-2, 2A, 3, 4-TETRAHYDRO-1H-CYCLOPENTA [CD] INDEN-7-YL) -OXY) -BENZONITRILE AND POLYMORPHS THEREOF | NIKANG THERAPEUTICS, INC. (US) | 2023-05-04 | — | — | WO | disclosed |
| WO-2022082337-A1 | PROCESS OF PREPARING 3-FLUORO-5 ( ( (1R, 2AR) -3, 3, 4, 4-TETRAFLUORO-1, 2A-DIHYDROXY-2, 2A, 3, 4-TETRAHYDRO-1H-CYCLOPENTA [CD] INDEN-7-YL) OXY) BENZONITRILE | NIKANG THERAPEUTICS, INC. (US) | 2022-04-28 | — | — | WO | disclosed |