Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2R | P25116 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 6/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | FBP1 | P09467 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21858005 | 1.00 | F2R (0.40) | F2RMAPTPOLBTSHRKMT2A | |
| SCHEMBL21857985 | 0.86 | F2R (0.41) | F2RMAPTPOLBTSHRKMT2A | |
| SCHEMBL21767653 | 0.80 | F2R (0.40) | F2RMAPTPOLBTSHRKMT2A | |
| SCHEMBL31072018 | 0.80 | F2R (0.40) | F2RMAPTPOLBTSHRKMT2A | |
| SCHEMBL5777608 | 0.79 | TSHR (0.55) | F2RMAPTPOLBTSHRKMT2A | |
| SCHEMBL25757435 | 0.79 | F2R (0.39) | F2RMAPTKMT2APKMSMN1; SMN2 | |
| SCHEMBL21858009 | 0.78 | MAPT (0.42) | MAPTPOLBTSHRKMT2AMEN1 | |
| SCHEMBL29622873 | 0.78 | MAPT (0.42) | MAPTPOLBTSHRKMT2AMEN1 | |
| SCHEMBL21857999 | 0.76 | F2R (0.41) | F2RMAPTPOLBTSHRKMT2A | |
| SCHEMBL21857875 | 0.76 | FBP1 (0.39) | MAPTPOLBTSHRKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115485262-B | Hypoxia inducible factor-2 (alpha) inhibitors and their use in the treatment of disease | 霖康疗法公司 | 2025-04-04 | — | — | CN | disclosed |
| CN-118993938-A | Tetrahydro-1H-cyclopenta [ CD ] indene derivatives as hypoxia inducible factor-2 (alpha) inhibitors | 尼坎治疗公司 | 2024-11-22 | — | — | CN | disclosed |
| CN-118993939-A | Tetrahydro-1H-cyclopenta [ CD ] indene derivatives as hypoxia inducible factor-2 (alpha) inhibitors | 尼坎治疗公司 | 2024-11-22 | — | — | CN | disclosed |
| CN-113874350-B | Tetrahydro-1H-cyclopenta [ CD ] indene derivatives as hypoxia inducible factor-2 (alpha) inhibitors | 尼坎治疗公司 | 2024-08-06 | — | — | CN | disclosed |
| CN-116507601-A | Process for preparing 3-fluoro-5- (((1S, 2 aR) -1,3, 4-pentafluoro-2 a-hydroxy-2, 2a,3, 4-tetrahydro-1H-cyclopenta [ cd ] inden-7-yl) oxy) benzonitrile | 尼坎治疗公司 | 2023-07-28 | — | — | CN | disclosed |
| WO-2023070483-A1 | PROCESSES OF MAKING 3-FLUORO-5- ( ( (1R, 2S, 2aS) -1, 2, 3, 3, 4, 4-HEXAFLUORO-2A-HYDROXY-2, 2A, 3, 4-TETRAHYDRO-1H-CYCLOPENTA [CD] INDEN-7-YL) -OXY) -BENZONITRILE AND POLYMORPHS THEREOF | NIKANG THERAPEUTICS, INC. (US) | 2023-05-04 | — | — | WO | disclosed |
| CN-115485262-A | Hypoxia inducible factor-2 (alpha) inhibitors and their use in the treatment of disease | 尼坎治疗公司 | 2022-12-16 | — | — | CN | disclosed |
| WO-2022082337-A1 | PROCESS OF PREPARING 3-FLUORO-5 ( ( (1R, 2AR) -3, 3, 4, 4-TETRAFLUORO-1, 2A-DIHYDROXY-2, 2A, 3, 4-TETRAHYDRO-1H-CYCLOPENTA [CD] INDEN-7-YL) OXY) BENZONITRILE | NIKANG THERAPEUTICS, INC. (US) | 2022-04-28 | — | — | WO | disclosed |