Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.41 |
| ▸ | GRM1 | Q13255 | 10/20 | 0.39 |
| ▸ | GRM5 | P41594 | 5/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.34 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.34 |
| ▸ | PRKACA | P17612 | 1/20 | 0.34 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | MARK3 | P27448 | 1/20 | 0.34 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20603935 | 1.00 | ALDH1A1 (0.44) | ALDH1A1SMN1; SMN2MKNK1MKNK2GRM1 | |
| SCHEMBL5109210 | 0.77 | ALDH1A1 (0.36) | ALDH1A1SMN1; SMN2MKNK1MKNK2FGFR1 | |
| SCHEMBL5118492 | 0.77 | PI4KA (0.51) | GRM1GRM5 | |
| SCHEMBL19350805 | 0.77 | FGFR1 (0.45) | ALDH1A1SMN1; SMN2MKNK1MKNK2FGFR1 | |
| SCHEMBL29623786 | 0.77 | FGFR1 (0.45) | ALDH1A1SMN1; SMN2MKNK1MKNK2FGFR1 | |
| SCHEMBL5111659 | 0.68 | PI4KA (0.47) | GRM1GRM5 | |
| SCHEMBL19350816 | 0.63 | ALDH1A1 (0.58) | ALDH1A1SMN1; SMN2GRM1GRM5FGFR1 | |
| SCHEMBL22143673 | 0.62 | MKNK1 (0.52) | ALDH1A1SMN1; SMN2MKNK1MKNK2FGFR1 | |
| SCHEMBL8856393 | 0.61 | CHEK1 (0.47) | ALDH1A1CHEK1AURKAPDPK1CHEK2 | |
| SCHEMBL19350758 | 0.60 | MKNK1 (0.46) | ALDH1A1SMN1; SMN2MKNK1MKNK2FGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3424924-B1 | UREA COMPOUND, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | ANCUREALL PHARMACEUTICAL SHANGHAI CO LTD (CN) | 2023-05-24 | — | — | EP | disclosed |
| CN-109071523-B | Urea compound, preparation method and medical application thereof | 恩瑞生物医药科技（上海）有限公司 | 2022-05-31 | — | — | CN | disclosed |