Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | PI4KA | P42356 | 3/20 | 0.42 |
| ▸ | PI4K2B | Q8TCG2 | 3/20 | 0.42 |
| ▸ | PI4K2A | Q9BTU6 | 3/20 | 0.42 |
| ▸ | PI4KB | Q9UBF8 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | XDH | P47989 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19350805 | 1.00 | FGFR1 (0.45) | FGFR1ALDH1A1SMN1; SMN2PI4KAPI4K2B | |
| SCHEMBL19350816 | 0.87 | ALDH1A1 (0.58) | FGFR1ALDH1A1SMN1; SMN2PI4KAPI4K2B | |
| SCHEMBL20627767 | 0.79 | ALDH1A1 (0.39) | FGFR1ALDH1A1SMN1; SMN2PI4KAPI4K2B | |
| SCHEMBL18292152 | 0.77 | PI4KA (0.62) | FGFR1ALDH1A1SMN1; SMN2PI4KAPI4K2B | |
| SCHEMBL19350813 | 0.77 | PI4KA (0.62) | FGFR1ALDH1A1SMN1; SMN2PI4KAPI4K2B | |
| SCHEMBL29623632 | 0.77 | ALDH1A1 (0.44) | FGFR1ALDH1A1SMN1; SMN2MKNK1MKNK2 | |
| SCHEMBL20603935 | 0.77 | ALDH1A1 (0.44) | FGFR1ALDH1A1SMN1; SMN2MKNK1MKNK2 | |
| SCHEMBL20201232 | 0.72 | PI4KA (0.49) | FGFR1ALDH1A1SMN1; SMN2PI4KAPI4K2B | |
| SCHEMBL5117930 | 0.68 | ALDH1A1 (0.35) | FGFR1ALDH1A1SMN1; SMN2PI4KAPI4K2B | |
| SCHEMBL28663481 | 0.67 | HPGD (0.52) | ALDH1A1SMN1; SMN2PI4KAPI4K2BPI4K2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3424924-B1 | UREA COMPOUND, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | ANCUREALL PHARMACEUTICAL SHANGHAI CO LTD (CN) | 2023-05-24 | — | — | EP | disclosed |
| CN-109071523-B | Urea compound, preparation method and medical application thereof | 恩瑞生物医药科技（上海）有限公司 | 2022-05-31 | — | — | CN | disclosed |