Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 2/20 | 0.61 |
| ▸ | PIM1 | P11309 | 1/20 | 0.61 |
| ▸ | CDK2 | P24941 | 1/20 | 0.61 |
| ▸ | GSK3B | P49841 | 1/20 | 0.61 |
| ▸ | KDR | P35968 | 1/20 | 0.59 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | CASP3 | P42574 | 1/20 | 0.55 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.55 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.55 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19350812 | 1.00 | AURKA (0.61) | AURKAPIM1CDK2GSK3BKDR | |
| SCHEMBL29623560 | 0.83 | TAAR1 (0.60) | AURKAKDRAURKBSMN1; SMN2HTT | |
| SCHEMBL19350760 | 0.83 | TAAR1 (0.60) | AURKAKDRAURKBSMN1; SMN2HTT | |
| SCHEMBL29623711 | 0.81 | AURKA (0.56) | AURKAKDRAURKBSMN1; SMN2MAPT | |
| SCHEMBL19350713 | 0.81 | AURKA (0.56) | AURKAKDRAURKBSMN1; SMN2MAPT | |
| SCHEMBL19350868 | 0.79 | AURKA (0.64) | AURKAKDRAURKBSMN1; SMN2HTT | |
| SCHEMBL20603923 | 0.78 | HTT (0.63) | AURKAKDRAURKBSMN1; SMN2HTT | |
| SCHEMBL29623720 | 0.78 | NPC1 (0.57) | AURKAKDRAURKBSMN1; SMN2MAPT | |
| SCHEMBL19350939 | 0.78 | NPC1 (0.57) | AURKAKDRAURKBSMN1; SMN2MAPT | |
| SCHEMBL19350864 | 0.77 | AURKA (0.61) | AURKAKDRAURKBSMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3424924-B1 | UREA COMPOUND, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | ANCUREALL PHARMACEUTICAL SHANGHAI CO LTD (CN) | 2023-05-24 | — | — | EP | disclosed |
| CN-109071523-B | Urea compound, preparation method and medical application thereof | 恩瑞生物医药科技（上海）有限公司 | 2022-05-31 | — | — | CN | disclosed |