Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.57 |
| ▸ | RAB9A | P51151 | 4/20 | 0.57 |
| ▸ | AURKA | O14965 | 1/20 | 0.57 |
| ▸ | KDR | P35968 | 1/20 | 0.57 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | RAF1 | P04049 | 1/20 | 0.52 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | F9 | P00740 | 2/20 | 0.43 |
| ▸ | F10 | P00742 | 2/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19350939 | 1.00 | NPC1 (0.57) | NPC1RAB9AAURKAKDRAURKB | |
| SCHEMBL29623560 | 0.79 | TAAR1 (0.60) | NPC1RAB9AAURKAKDRAURKB | |
| SCHEMBL19350760 | 0.79 | TAAR1 (0.60) | NPC1RAB9AAURKAKDRAURKB | |
| SCHEMBL11714626 | 0.78 | RAB9A (0.75) | NPC1RAB9AMAPTRAF1ALDH1A1 | |
| SCHEMBL19350812 | 0.78 | AURKA (0.61) | NPC1RAB9AAURKAKDRAURKB | |
| SCHEMBL29623716 | 0.78 | AURKA (0.61) | NPC1RAB9AAURKAKDRAURKB | |
| SCHEMBL19350868 | 0.78 | AURKA (0.64) | NPC1RAB9AAURKAKDRAURKB | |
| SCHEMBL29623711 | 0.77 | AURKA (0.56) | NPC1RAB9AAURKAKDRAURKB | |
| SCHEMBL19350713 | 0.77 | AURKA (0.56) | NPC1RAB9AAURKAKDRAURKB | |
| SCHEMBL29623374 | 0.76 | MEN1 (0.63) | NPC1RAB9AAURKAKDRAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3424924-B1 | UREA COMPOUND, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | ANCUREALL PHARMACEUTICAL SHANGHAI CO LTD (CN) | 2023-05-24 | — | — | EP | disclosed |
| CN-109071523-B | Urea compound, preparation method and medical application thereof | 恩瑞生物医药科技（上海）有限公司 | 2022-05-31 | — | — | CN | disclosed |