Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.58 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.54 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.54 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | QPCT | Q16769 | 2/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | CDYL2 | Q8N8U2 | 1/20 | 0.44 |
| ▸ | CDYL | Q9Y232 | 1/20 | 0.44 |
| ▸ | CDY1; CDY1B | Q9Y6F8 | 1/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10603795 | 0.98 | MTNR1A (0.59) | MTNR1AMTNR1BHTTALDH1A1HPGD | |
| SCHEMBL19911346 | 0.86 | MTNR1A (0.64) | MTNR1AMTNR1BHTTALDH1A1HPGD | |
| SCHEMBL6758619 | 0.85 | NPC1 (0.65) | MTNR1AMTNR1BALDH1A1HPGDMAPT | |
| SCHEMBL19911355 | 0.84 | MTNR1A (0.58) | MTNR1AMTNR1BHTTALDH1A1HPGD | |
| SCHEMBL19911358 | 0.83 | MTNR1A (0.61) | MTNR1AMTNR1BHTTALDH1A1HPGD | |
| SCHEMBL12479232 | 0.81 | MTNR1A (0.66) | MTNR1AMTNR1BHTTALDH1A1HPGD | |
| SCHEMBL19611398 | 0.81 | MTNR1A (0.62) | MTNR1AMTNR1BHTTALDH1A1HPGD | |
| SCHEMBL9120412 | 0.81 | MTNR1A (0.62) | MTNR1AMTNR1BHTTALDH1A1HPGD | |
| SCHEMBL12479984 | 0.81 | MTNR1A (0.62) | MTNR1AMTNR1BHTTALDH1A1HPGD | |
| SCHEMBL9040429 | 0.80 | MTNR1A (0.61) | MTNR1AMTNR1BHTTALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110214141-B | Benzodiazolium compounds as ENaC inhibitors | 企业治疗学有限公司 | 2022-05-31 | — | — | CN | disclosed |