Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPMT | P51580 | 1/20 | 0.42 |
| ▸ | MRGPRX4 | Q96LA9 | 3/20 | 0.40 |
| ▸ | TTR | P02766 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CA3 | P07451 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | SELL | P14151 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | SELP | P16109 | 1/20 | 0.38 |
| ▸ | FUT4 | P22083 | 1/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | CA6 | P23280 | 1/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24275875 | 1.00 | TPMT (0.42) | TPMTMRGPRX4TTRLMNAMAPK1 | |
| SCHEMBL29234169 | 0.84 | CES1 (0.38) | KCNQ3KCNQ2KCNE1KCNQ1PPARG | |
| SCHEMBL20703148 | 0.84 | KIF11 (0.49) | CA5AKCNQ3KCNQ2KCNE1KCNQ1 | |
| SCHEMBL1001361 | 0.82 | TPMT (0.54) | TPMTTTRLMNAMAPK1KDM4E | |
| SCHEMBL627998 | 0.81 | CES2 (0.45) | TPMTMRGPRX4TTRLMNAMAPK1 | |
| SCHEMBL29738542 | 0.81 | CES2 (0.45) | TPMTMRGPRX4TTRLMNAMAPK1 | |
| SCHEMBL20702680 | 0.80 | GSK3B (0.45) | MRGPRX4KCNQ3KCNQ2KCNE1KCNQ1 | |
| SCHEMBL19151611 | 0.78 | HDAC1 (0.43) | MRGPRX4TTRLMNAMAPK1KDM4E | |
| SCHEMBL3230982 | 0.78 | TTR (0.48) | TPMTMRGPRX4TTRHCAR1DAO | |
| SCHEMBL29738557 | 0.78 | TTR (0.48) | TPMTMRGPRX4TTRHCAR1DAO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022053010-A1 | FUSED RING PYRIMIDONE DERIVATIVES FOR USE IN THE TREATMENT OF HBV INFECTION OR OF HBV-INDUCED DISEASES | Janssen Sciences Ireland Unlimited Company (IE) | 2022-03-17 | — | — | WO | disclosed |