Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | NOTUM | Q6P988 | 4/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.48 |
| ▸ | PLK1 | P53350 | 1/20 | 0.44 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | CNR2 | P34972 | 3/20 | 0.42 |
| ▸ | CNR1 | P21554 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29626160 | 0.83 | MAPK1 (0.44) | ALDH1A1NOTUMMAPK1HPGDSMN1; SMN2 | |
| SCHEMBL29626109 | 0.81 | TYRO3 (0.45) | ALDH1A1NOTUMMAPK1HPGDALOX15 | |
| SCHEMBL6457336 | 0.79 | PLK1 (0.69) | ALDH1A1NOTUMHPGDALOX15TSHR | |
| SCHEMBL19377726 | 0.79 | NOTUM (0.59) | ALDH1A1NOTUMMAPK1HPGDSMN1; SMN2 | |
| SCHEMBL29908822 | 0.79 | ALDH1A1 (0.46) | ALDH1A1NOTUMMAPK1HPGDALOX15 | |
| SCHEMBL29626240 | 0.78 | GAA (0.46) | ALDH1A1HPGDALOX15SMN1; SMN2LMNA | |
| SCHEMBL29626227 | 0.76 | GRM2 (0.50) | ALDH1A1MAPK1MAPTKDM4E | |
| SCHEMBL29812604 | 0.76 | NOTUM (0.48) | ALDH1A1NOTUMHPGDSMN1; SMN2LMNA | |
| SCHEMBL29812304 | 0.74 | NOTUM (0.49) | ALDH1A1NOTUMHPGDSMN1; SMN2RAB9A | |
| SCHEMBL29812432 | 0.74 | NOTUM (0.49) | ALDH1A1NOTUMHPGDSMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114456176-A | Pyrrolotriazine compounds as TAM inhibitors | 因赛特公司 | 2022-05-10 | — | — | CN | claimed |
| CN-114456175-A | Pyrrolotriazine compounds as TAM inhibitors | 因赛特公司 | 2022-05-10 | — | — | CN | disclosed |
| CN-114456176-A | Pyrrolotriazine compounds as TAM inhibitors | 因赛特公司 | 2022-05-10 | — | — | CN | disclosed |