Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.46 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.46 |
| ▸ | MYC | P01106 | 6/20 | 0.45 |
| ▸ | NR4A1 | P22736 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 6/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | APEX1 | P27695 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | HSPA1A | P0DMV8 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL680769 | 0.86 | ALDH1A1 (0.57) | ALDH1A1NOTUMMYCNR4A1MAPT | |
| SCHEMBL30174168 | 0.84 | TDP1 (0.44) | ALDH1A1MYCMAPTKDM4EHPGD | |
| SCHEMBL28288439 | 0.84 | L3MBTL1 (0.50) | ALDH1A1NOTUMMYCNR4A1MAPT | |
| SCHEMBL30174246 | 0.82 | MKNK1 (0.47) | ALDH1A1MYCMAPTKDM4EHPGD | |
| SCHEMBL30174288 | 0.81 | MAPT (0.36) | ALDH1A1MYCNR4A1MAPTKDM4E | |
| SCHEMBL18044750 | 0.81 | MYC (0.58) | ALDH1A1NOTUMMYCMAPTKDM4E | |
| SCHEMBL29625549 | 0.79 | ALDH1A1 (0.53) | ALDH1A1NOTUMMAPK1MAPTKDM4E | |
| SCHEMBL30174316 | 0.78 | NR4A1 (0.36) | ALDH1A1MYCNR4A1MAPTKDM4E | |
| SCHEMBL3061680 | 0.78 | ALDH1A1 (0.57) | ALDH1A1MAPK1MAPTKDM4EHPGD | |
| SCHEMBL30174273 | 0.78 | MYC (0.35) | ALDH1A1MYCNR4A1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111295386-B | Thienopyridine derivatives and pharmaceutical compositions containing the same | 伟迈可生物有限公司 | 2022-09-06 | — | — | CN | claimed |
| EP-3436461-B1 | PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS | INCYTE CORP (US) | 2023-11-01 | — | — | EP | disclosed |
| CN-116685324-A | Pharmaceutical composition for preventing or treating pancreatic cancer associated with RON mutation and method of using the same | 伟迈可生物有限公司 | 2023-09-01 | — | — | CN | disclosed |
| CN-116390729-A | Pharmaceutical composition for preventing or treating non-small cell lung cancer associated with RON mutation and method of using the same | 伟迈可生物有限公司 | 2023-07-04 | — | — | CN | disclosed |
| CN-115916210-A | Pharmaceutical composition for preventing or treating small cell lung cancer associated with RON mutation and method of using the same | 伟迈可生物有限公司 | 2023-04-04 | — | — | CN | disclosed |
| CN-115209900-A | Pharmaceutical composition for preventing or treating cancer in which KRAS mutation and activated RON are present | 伟迈可生物有限公司 | 2022-10-18 | — | — | CN | disclosed |
| CN-115003307-A | Pharmaceutical composition for preventing or treating cancers associated with KRAS mutations | 伟迈可生物有限公司 | 2022-09-02 | — | — | CN | disclosed |