Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 12/20 | 0.55 |
| ▸ | NTRK2 | Q16620 | 12/20 | 0.55 |
| ▸ | IGF1R | P08069 | 4/20 | 0.55 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.55 |
| ▸ | NTRK3 | Q16288 | 9/20 | 0.44 |
| ▸ | EPAS1 | Q99814 | 4/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | BCAT2 | O15382 | 2/20 | 0.37 |
| ▸ | BCAT1 | P54687 | 2/20 | 0.37 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ponazuril SCHEMBL203030 | 1.00 | NTRK1 (0.55) | NTRK1NTRK2IGF1RFGFR1NTRK3 | |
| SCHEMBL10527532 | 0.89 | NTRK1 (0.55) | NTRK1NTRK2IGF1RFGFR1NTRK3 | |
| SCHEMBL10528041 | 0.89 | EPAS1 (0.44) | NTRK1NTRK2IGF1RFGFR1NTRK3 | |
| SCHEMBL11475552 | 0.89 | NTRK1 (0.44) | NTRK1NTRK2IGF1RFGFR1NTRK3 | |
| SCHEMBL20306614 | 0.89 | NTRK1 (0.72) | NTRK1NTRK2IGF1RFGFR1NTRK3 | |
| SCHEMBL11474624 | 0.89 | NTRK1 (0.56) | NTRK1NTRK2IGF1RFGFR1NTRK3 | |
| SCHEMBL10525700 | 0.88 | NTRK1 (0.39) | NTRK1NTRK2IGF1RFGFR1NTRK3 | |
| SCHEMBL13780151 | 0.87 | NTRK1 (0.60) | NTRK1NTRK2IGF1RFGFR1NTRK3 | |
| SCHEMBL10527978 | 0.87 | NTRK1 (0.49) | NTRK1NTRK2IGF1RFGFR1NTRK3 | |
| SCHEMBL11490392 | 0.85 | NTRK1 (0.41) | NTRK1NTRK2IGF1RFGFR1NTRK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4021573-A1 | TRIAZINE DERIVATIVES FOR TREATING DISEASES RELATING TO NEUROTROPHINS | Alzecure Pharma AB (SE) | 2022-07-06 | — | — | EP | disclosed |
| CN-114423743-A | Triazine derivatives for the treatment of diseases associated with neurotrophic factors | 阿泽克制药公司 | 2022-04-29 | — | — | CN | disclosed |