Ponazuril

Ponazuril

SCHEMBL203030

Cc1cc(-n2c(=O)[nH]c(=O)n(C)c2=O)ccc1Oc1ccc(S(=O)(=O)C(F)(F)F)cc1

nearest known ligand 0.55

Full drug profile on Sugi Atlas →

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
NTRK1 P04629 12/20 0.55
NTRK2 Q16620 12/20 0.55
IGF1R P08069 4/20 0.55
FGFR1 P11362 4/20 0.55
NTRK3 Q16288 9/20 0.44
EPAS1 Q99814 4/20 0.39
PTPN1 P18031 1/20 0.39
BCAT2 O15382 2/20 0.37
BCAT1 P54687 2/20 0.37
ALDH3A1 P30838 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Ponazuril SCHEMBL29625926 1.00 NTRK1 (0.55) NTRK1NTRK2IGF1RFGFR1NTRK3
SCHEMBL10527532 0.89 NTRK1 (0.55) NTRK1NTRK2IGF1RFGFR1NTRK3
SCHEMBL10528041 0.89 EPAS1 (0.44) NTRK1NTRK2IGF1RFGFR1NTRK3
SCHEMBL11475552 0.89 NTRK1 (0.44) NTRK1NTRK2IGF1RFGFR1NTRK3
SCHEMBL20306614 0.89 NTRK1 (0.72) NTRK1NTRK2IGF1RFGFR1NTRK3
SCHEMBL11474624 0.89 NTRK1 (0.56) NTRK1NTRK2IGF1RFGFR1NTRK3
SCHEMBL10525700 0.88 NTRK1 (0.39) NTRK1NTRK2IGF1RFGFR1NTRK3
SCHEMBL13780151 0.87 NTRK1 (0.60) NTRK1NTRK2IGF1RFGFR1NTRK3
SCHEMBL10527978 0.87 NTRK1 (0.49) NTRK1NTRK2IGF1RFGFR1NTRK3
SCHEMBL11490392 0.85 NTRK1 (0.41) NTRK1NTRK2IGF1RFGFR1NTRK3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1386 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4082524-B1 TRIAZINE FORMULATIONS CEVA SANTE ANIMALE SA (FR) 2025-02-26 EP claimed
WO-2024138230-A1 FORMULATION AND METHOD FOR TREATMENT OF INFECTIONS VETERINARY PHARMACY CORPORATION (US) 2024-06-27 WO claimed
US-11246836-B2 Intramuscular depot of decoquinate compositions and method of prophylaxis and treatment thereof BLUELIGHT PHARMATECH CO., LTD. (CN) 2022-02-15 US claimed
CN-113999096-A Method for synthesizing 6-methyl-5-octen-2-one by condensation hydrogenation 万华化学集团股份有限公司 2022-02-01 CN claimed
US-20220008542-A1 ANTI-PROTOZOAL COMPOUNDS AND USES THEREOF UNIV AUBURN (US) 2022-01-13 US claimed
US-11160867-B2 Anti-protozoal compounds and uses thereof AUBURN UNIVERSITY (US) 2021-11-02 US claimed
CN-113209016-A Iron dextran and palustralin suspension injection and preparation method thereof 湖北龙翔药业科技股份有限公司 2021-08-06 CN claimed
CN-113197849-A Suspension injection containing iron glucoheptonate and ponazuril and preparation method thereof 湖北龙翔药业科技股份有限公司 2021-08-03 CN claimed
US-20210228613-A1 FORMULATIONS CONTAINING TRIAZINONES AND IRON WITH A LOW AMOUNT OF FREE IRON IONS BAYER ANIMAL HEALTH GMBH (DE) 2021-07-29 US claimed
EP-3801540-A1 FORMULATIONS CONTAINING TRIAZINONES AND IRON WITH A LOW AMOUNT OF FREE IRON IONS Bayer Animal Health GmbH (DE) 2021-04-14 EP claimed
CN-1331594-A Triazineone compounds for treating diseases due to sarcosystis, neospora and toxoplasma BAYER AG (US) 2002-01-16 CN claimed
EP-1140101-A1 TRIAZINEONE COMPOUNDS FOR TREATING DISEASES DUE TO SARCOSYSTIS, NEOSPORA AND TOXOPLASMA Bayer Corporation (US) 2001-10-10 EP claimed
EP-1140103-A2 TRIAZINEONE COMPOUNDS FOR TREATING DISEASES DUE TO SARCOSYSTIS, NEOSPORA AND TOXOPLASMA Bayer Corporation (US) 2001-10-10 EP claimed
EP-1140102-A2 TRIAZINEONE COMPOUNDS FOR TREATING DISEASES DUE TO SARCOSYSTIS, NEOSPORA AND TOXOPLASMA Bayer Corporation (US) 2001-10-10 EP claimed
WO-2001039778-A2 TRIAZINONE COMPOUNDS FOR TREATING DISEASES RESULTING FROM INFESTATION WITH PARASITIC PROTOZOANS BAYER AKTIENGESELLSCHAFT (DE) 2001-06-07 WO claimed
US-6194408-B1 PARASITICIDES BAYER CORPORATION 2001-02-27 US claimed
US-6150361-A THERAPEUTICALLY TREATING A DISEASED ANIMAL SUFFERING FROM A PARASITIC NEUROLOGIC OR ABORTIGENIC DISEASE COMPRISING ADMINISTERING THE ANIMAL PONAZURIL, A TRIAZINEONE COMPOUND BAYER CORPORATION (US) 2000-11-21 US claimed
WO-2000037084-A1 TRIAZINEONE COMPOUNDS FOR TREATING DISEASES DUE TO SARCOSYSTIS, NEOSPORA AND TOXOPLASMA BAYER CORPORATION (US) 2000-06-29 WO claimed
WO-2000037064-A2 TRIAZINEONE COMPOUNDS FOR TREATING DISEASES DUE TO SARCOSYSTIS, NEOSPORA AND TOXOPLASMA BAYER CORPORATION (US) 2000-06-29 WO claimed
WO-2000037063-A2 TRIAZINEONE COMPOUNDS FOR TREATING DISEASES DUE TO SARCOSYSTIS, NEOSPORA AND TOXOPLASMA BAYER CORPORATION (US) 2000-06-29 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220008542-A1 ANTI-PROTOZOAL COMPOUNDS AND USES THEREOF PPIP5K2, PIGS, PGLS NTRK1 4841/4885NTRK2 4873/4885IGF1R 4879/4885
US-11160867-B2 Anti-protozoal compounds and uses thereof PPIP5K2, PIGS, PGLS NTRK1 4841/4885NTRK2 4873/4885IGF1R 4879/4885
US-11246836-B2 Intramuscular depot of decoquinate compositions and method of prophylaxis and treatment thereof HMGCR, DECR1, GYS1 NTRK1 4779/4885NTRK2 3889/4885IGF1R 2810/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.