Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25408527 | 0.75 | KDM4E (0.42) | KDM4EMEN1KMT2AMAPTALOX15 | |
| SCHEMBL22917536 | 0.72 | ADRA1D (0.42) | KDM4EMEN1KMT2AMAPTALOX15 | |
| SCHEMBL12500825 | 0.67 | KDM4E (0.41) | KDM4EMEN1KMT2AMAPTALOX15 | |
| SCHEMBL22574714 | 0.67 | GAA (0.45) | KDM4EMEN1KMT2AMAPTALOX15 | |
| SCHEMBL21419870 | 0.66 | KDM4E (0.40) | KDM4EMEN1KMT2AMAPTALOX15 | |
| SCHEMBL16863288 | 0.66 | KMT2A (0.40) | KDM4EMEN1KMT2AMAPTALOX15 | |
| SCHEMBL23331324 | 0.64 | KDM4E (0.39) | KDM4EMEN1KMT2AMAPTALOX15 | |
| SCHEMBL21229304 | 0.64 | CA12 (0.40) | KDM4EMEN1KMT2AMAPTALOX15 | |
| SCHEMBL352579 | 0.64 | CYP1A2 (0.54) | KDM4EMEN1KMT2AMAPTPDE4D | |
| SCHEMBL4827391 | 0.64 | CYP1A2 (0.48) | KDM4EMEN1KMT2AMAPTALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114456175-A | Pyrrolotriazine compounds as TAM inhibitors | 因赛特公司 | 2022-05-10 | — | — | CN | disclosed |
| CN-114456176-A | Pyrrolotriazine compounds as TAM inhibitors | 因赛特公司 | 2022-05-10 | — | — | CN | disclosed |