Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTAFR | P25105 | 10/20 | 1.00 |
| ▸ | SLC6A15 | Q9H2J7 | 10/20 | 1.00 |
| ▸ | HRH1 | P35367 | 5/20 | 1.00 |
| ▸ | FNTA | P49354 | 2/20 | 1.00 |
| ▸ | FNTB | P49356 | 2/20 | 1.00 |
| ▸ | MEN1 | O00255 | 1/20 | 0.76 |
| ▸ | NPC1 | O15118 | 1/20 | 0.76 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.76 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.76 |
| ▸ | GMNN | O75496 | 1/20 | 0.76 |
| ▸ | USP2 | O75604 | 1/20 | 0.76 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.76 |
| ▸ | LMNA | P02545 | 1/20 | 0.76 |
| ▸ | TP53 | P04637 | 1/20 | 0.76 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.76 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.76 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.76 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.76 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.76 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.76 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sch-37370 SCHEMBL29754039 | 1.00 | PTAFR (1.00) | PTAFRSLC6A15HRH1FNTAFNTB | |
| Sch-37370 SCHEMBL3071641 | 1.00 | PTAFR (1.00) | PTAFRSLC6A15HRH1FNTAFNTB | |
| SCHEMBL8878121 | 0.93 | SLC6A15 (0.86) | PTAFRSLC6A15HRH1FNTAFNTB | |
| SCHEMBL8880503 | 0.91 | PTAFR (1.00) | PTAFRSLC6A15HRH1FNTAFNTB | |
| SCHEMBL3367280 | 0.90 | SLC6A15 (0.82) | PTAFRSLC6A15HRH1FNTAFNTB | |
| SCHEMBL8880239 | 0.90 | PTAFR (1.00) | PTAFRSLC6A15HRH1FNTAFNTB | |
| SCHEMBL8878295 | 0.89 | SLC6A15 (0.80) | PTAFRSLC6A15HRH1FNTAFNTB | |
| SCHEMBL8889578 | 0.89 | SLC6A15 (0.79) | PTAFRSLC6A15HRH1FNTAFNTB | |
| SCHEMBL8878098 | 0.89 | SLC6A15 (1.00) | PTAFRSLC6A15HRH1FNTAFNTB | |
| SCHEMBL8878015 | 0.89 | SLC6A15 (0.86) | PTAFRSLC6A15HRH1FNTAFNTB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114616229-A | Tricyclic compounds and pharmaceutical uses thereof | 镇斗生物科技股份公司 | 2022-06-10 | — | — | CN | claimed |
| CN-114616229-B | Tricyclic compounds and pharmaceutical uses thereof | 镇斗生物科技股份公司 | 2024-09-03 | — | — | CN | disclosed |
| US-20230002349-A1 | TRICYCLIC COMPOUND AND PHARMACEUTICAL USE THEREOF | JD BIOSCIENCE INC. (KR) | 2023-01-05 | — | — | US | disclosed |
| EP-4053116-A1 | TRICYCLIC COMPOUND AND PHARMACEUTICAL USE THEREOF | JD Bioscience Inc. (KR) | 2022-09-07 | — | — | EP | disclosed |
| CN-114616229-A | Tricyclic compounds and pharmaceutical uses thereof | 镇斗生物科技股份公司 | 2022-06-10 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230002349-A1 | TRICYCLIC COMPOUND AND PHARMACEUTICAL USE THEREOF | TPH1, SLC6A4, TPH2 | PTAFR 1723/4885SLC6A15 28/4885HRH1 1035/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.