Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.39 |
| ▸ | ATR | Q13535 | 1/20 | 0.39 |
| ▸ | ATRIP | Q8WXE1 | 1/20 | 0.39 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.39 |
| ▸ | AKT2 | P31751 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | NUDT1 | P36639 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.35 |
| ▸ | NCF1 | P14598 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.35 |
| ▸ | CDC42BPB | Q9Y5S2 | 3/20 | 0.35 |
| ▸ | METAP2 | P50579 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31513726 | 0.77 | PIK3CD (0.35) | PIK3CAPIK3CDPIK3CBACVR1HTT | |
| SCHEMBL28741988 | 0.75 | HSP90AA1 (0.43) | HSP90AA1HSP90AB1ATRATRIPLMNA | |
| SCHEMBL31092002 | 0.75 | HSP90AA1 (0.43) | HSP90AA1HSP90AB1ATRATRIPLMNA | |
| SCHEMBL29626563 | 0.72 | HSP90AA1 (0.40) | HSP90AA1HSP90AB1ATRATRIPAKT2 | |
| SCHEMBL10564742 | 0.68 | PARP1 (0.39) | ATRATRIPALDH1A1 | |
| SCHEMBL15421896 | 0.67 | AKT2 (0.48) | AKT2NUDT1ROCK2ROCK1CDC42BPB | |
| SCHEMBL12612274 | 0.67 | AKT2 (0.48) | AKT2NUDT1ROCK2ROCK1CDC42BPB | |
| SCHEMBL3466097 | 0.66 | HTT (0.41) | ACVR1HTT | |
| SCHEMBL29951183 | 0.65 | HTT (0.41) | ACVR1HTTMETAP2 | |
| SCHEMBL25584612 | 0.65 | CYP46A1 (0.42) | HSP90AA1HSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114450271-B | Ureas, amino and substituted heteroaryl compounds for Cbl-b inhibition | 纽力克斯治疗公司 | 2024-09-20 | — | — | CN | disclosed |
| EP-4003965-A1 | UREA, AMIDE, AND SUBSTITUTED HETEROARYL COMPOUNDS FOR CBL-B INHIBITION | Nurix Therapeutics, Inc. (US) | 2022-06-01 | — | — | EP | disclosed |