Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.43 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.43 |
| ▸ | ATR | Q13535 | 2/20 | 0.37 |
| ▸ | ATRIP | Q8WXE1 | 2/20 | 0.37 |
| ▸ | CLK2 | P49760 | 1/20 | 0.34 |
| ▸ | CLK3 | P49761 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.33 |
| ▸ | SGK1 | O00141 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMO | Q99835 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.32 |
| ▸ | TDO2 | P48775 | 1/20 | 0.32 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.32 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.32 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28741988 | 1.00 | HSP90AA1 (0.43) | HSP90AA1HSP90AB1ATRATRIPCLK2 | |
| SCHEMBL29626604 | 0.75 | HSP90AA1 (0.44) | HSP90AA1HSP90AB1ATRATRIPLMNA | |
| SCHEMBL19743438 | 0.69 | NOS1 (0.33) | HTTTDO2JAK2JAK1TYK2 | |
| SCHEMBL901730 | 0.68 | GRM2 (0.42) | HSP90AA1HSP90AB1LMNAHTTSMO | |
| SCHEMBL26604120 | 0.67 | LMNA (0.45) | LMNAHTTSMO | |
| SCHEMBL30911486 | 0.67 | IRAK4 (0.39) | HSP90AA1HSP90AB1ATRATRIPLMNA | |
| SCHEMBL31091998 | 0.67 | ADRB2 (0.37) | — | |
| SCHEMBL10806175 | 0.66 | NPY5R (0.53) | NPY5RPOLBHTTALDH1A1 | |
| SCHEMBL23037243 | 0.65 | PBRM1 (0.57) | HSP90AA1HSP90AB1ATRATRIPLMNA | |
| SCHEMBL5429458 | 0.65 | LMNA (0.46) | CLK2CLK3DYRK1ANPY5RLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114450271-B | Ureas, amino and substituted heteroaryl compounds for Cbl-b inhibition | 纽力克斯治疗公司 | 2024-09-20 | — | — | CN | disclosed |