Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 10/20 | 1.00 |
| ▸ | METAP2 | P50579 | 9/20 | 0.58 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.55 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.53 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.49 |
| ▸ | XDH | P47989 | 1/20 | 0.48 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.48 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.48 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.48 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.48 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28741857 | 1.00 | IDO1 (1.00) | IDO1METAP2KEAP1CLK4SIRT3 | |
| SCHEMBL28321674 | 0.80 | IDO1 (0.66) | IDO1METAP2KEAP1SIRT3 | |
| SCHEMBL28741785 | 0.79 | IDO1 (0.65) | IDO1METAP2KEAP1SIRT3 | |
| SCHEMBL171405 | 0.75 | IDO1 (0.59) | IDO1CLK4XDHGABRG2GABRB3 | |
| SCHEMBL31339117 | 0.75 | IDO1 (0.59) | IDO1CLK4XDHGABRG2GABRB3 | |
| SCHEMBL98912 | 0.75 | IDO1 (0.59) | IDO1CLK4XDHGABRG2GABRB3 | |
| SCHEMBL31173290 | 0.74 | IDO1 (1.00) | IDO1METAP2KEAP1SIRT3 | |
| SCHEMBL481943 | 0.74 | IDO1 (1.00) | IDO1METAP2KEAP1SIRT3 | |
| SCHEMBL13993856 | 0.74 | METAP2 (1.00) | IDO1METAP2KEAP1SIRT3 | |
| SCHEMBL4701290 | 0.73 | GP6 (0.60) | IDO1CLK4XDH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114450271-B | Ureas, amino and substituted heteroaryl compounds for Cbl-b inhibition | 纽力克斯治疗公司 | 2024-09-20 | — | — | CN | disclosed |
| EP-4003965-A1 | UREA, AMIDE, AND SUBSTITUTED HETEROARYL COMPOUNDS FOR CBL-B INHIBITION | Nurix Therapeutics, Inc. (US) | 2022-06-01 | — | — | EP | disclosed |
| CN-114450271-A | Ureas, amino and substituted heteroaryl compounds for Cbl-b inhibition | 纽力克斯治疗公司 | 2022-05-06 | — | — | CN | disclosed |