Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 1/20 | 0.41 |
| ▸ | CCR5 | P51681 | 1/20 | 0.41 |
| ▸ | CCR8 | P51685 | 1/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 7/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.33 |
| ▸ | RAF1 | P04049 | 1/20 | 0.33 |
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.32 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | CYP2C8 | P10632 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | IDO1 | P14902 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2628883 | 0.72 | CCR1 (0.42) | CCR1CCR5CCR8LMNATRIM24 | |
| SCHEMBL2596969 | 0.71 | NCF1 (0.41) | TGFBR1HTTPTK2CYP3A4CYP2C8 | |
| SCHEMBL3465347 | 0.71 | NOS1 (0.47) | TGFBR1HTTPTK2BRAFCYP3A4 | |
| SCHEMBL2598373 | 0.71 | MAPKAPK2 (0.38) | TGFBR1HTTPTK2CYP3A4CYP2C8 | |
| SCHEMBL3466097 | 0.71 | HTT (0.41) | TGFBR1HTTPTK2RAF1BRAF | |
| SCHEMBL29514304 | 0.71 | NOS1 (0.47) | TGFBR1HTTPTK2CYP3A4CYP2C8 | |
| SCHEMBL2598398 | 0.71 | NOS1 (0.47) | TGFBR1HTTPTK2CYP3A4CYP2C8 | |
| SCHEMBL19152664 | 0.71 | HTT (0.45) | CCR1CCR5CCR8TGFBR1HTT | |
| SCHEMBL15532523 | 0.70 | CCR1 (0.50) | CCR1CCR5CCR8RAF1BRAF | |
| SCHEMBL29935797 | 0.70 | CCR1 (0.50) | CCR1CCR5CCR8RAF1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220340893-A1 | BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES | NUEVOLUTION A/S (DK) | 2022-10-27 | — | — | US | disclosed |
| EP-4003965-A1 | UREA, AMIDE, AND SUBSTITUTED HETEROARYL COMPOUNDS FOR CBL-B INHIBITION | Nurix Therapeutics, Inc. (US) | 2022-06-01 | — | — | EP | disclosed |
| CN-114450271-A | Ureas, amino and substituted heteroaryl compounds for Cbl-b inhibition | 纽力克斯治疗公司 | 2022-05-06 | — | — | CN | disclosed |