Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | FDPS | P14324 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | ALPL | P05186 | 2/20 | 0.41 |
| ▸ | ALPG | P10696 | 2/20 | 0.41 |
| ▸ | ALPI | P09923 | 1/20 | 0.41 |
| ▸ | PLAA | Q9Y263 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2970107 | 0.85 | ALDH1A1 (0.53) | KMT2AALDH1A1POLBCA12CA1 | |
| SCHEMBL2960305 | 0.83 | ALPL (0.50) | KMT2AALDH1A1POLBSMN1; SMN2KDM4E | |
| SCHEMBL2633151 | 0.83 | KMT2A (0.50) | KMT2AALDH1A1POLBCA12CA1 | |
| SCHEMBL16093158 | 0.82 | KMT2A (0.44) | KMT2AALDH1A1POLBCA12CA1 | |
| SCHEMBL16364921 | 0.82 | TLR8 (0.50) | KMT2AALDH1A1SMN1; SMN2HTTTSHR | |
| SCHEMBL9726075 | 0.82 | SMN1; SMN2 (0.41) | KMT2AALDH1A1SMN1; SMN2HTTTSHR | |
| SCHEMBL5707866 | 0.81 | KMT2A (0.49) | KMT2AALDH1A1POLBCA12CA1 | |
| SCHEMBL18510088 | 0.81 | ALDH1A1 (0.49) | KMT2AALDH1A1POLBCA12CA1 | |
| SCHEMBL17916298 | 0.81 | ALDH1A1 (0.49) | KMT2AALDH1A1POLBCA12CA1 | |
| SCHEMBL992745 | 0.81 | SMN1; SMN2 (0.61) | KMT2AALDH1A1POLBCA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023183616-A1 | NOVEL IONIZABLE LIPIDS AND LIPID NANOPARTICLES AND METHODS OF USING THE SAME | SENDA BIOSCIENCES, INC. (US) | 2023-09-28 | — | — | WO | disclosed |
| EP-3037452-B1 | ONE-PART CURABLE RESIN COMPOSITION | ADEKA CORP (JP) | 2019-04-10 | — | — | EP | disclosed |
| US-9757944-B2 | Liquid jet head and method for producing same, and liquid jet apparatus and image forming apparatus | RICOH COMPANY, LTD. (JP) | 2017-09-12 | — | — | US | disclosed |
| US-20170043580-A1 | LIQUID JET HEAD AND METHOD FOR PRODUCING SAME, AND LIQUID JET APPARATUS AND IMAGE FORMING APPARATUS | RICOH COMPANY, LTD. (JP) | 2017-02-16 | — | — | US | disclosed |
| CN-103980204-B | Ionic liquid-catalyzed amine and α, β-unsaturated electron deficiency receptor method | TAIZHOU UNIVERSITY (CN) | 2016-03-30 | — | — | CN | disclosed |
| CN-103980204-A | Method for catalyzing amines and alpha, beta-unsaturated electron-deficient acceptors by ionic liquid | UNIV TAIZHOU | 2014-08-13 | — | — | CN | disclosed |
| US-7763728-B2 | Tetrahydropyridothiophenes | 4SC AG (DE) | 2010-07-27 | — | — | US | disclosed |
| US-7714136-B2 | Tetrahydropyridothiophenes | 4SC AG (DE) | 2010-05-11 | — | — | US | disclosed |
| US-20090258873-A1 | Novel tetrahydropyridothiophenes | PEKARI KLAUS | 2009-10-15 | — | — | US | disclosed |
| US-20090257977-A1 | NOVEL TETRAHYDROPYRIDOTHIOPHENES | PEKARI KLAUS | 2009-10-15 | — | — | US | disclosed |
| US-20080260749-A1 | Novel Tetrahydropyridothiophenes | NYCOMED GMBH (DE) | 2008-10-23 | — | — | US | disclosed |
| US-20080206258-A1 | Novel Tetrahydropyridothiophenes | NYCOMED GMBH (DE) | 2008-08-28 | — | — | US | disclosed |
| EP-1896484-A2 | TETRAHYDROPYRIDOTHIOPHENES FOR USE IN THE TREATMENT OF CANCER | Nycomed GmbH (DE) | 2008-03-12 | — | — | EP | disclosed |
| EP-1893618-A2 | TETRAHYDROPYRIDOTHIOPHENES FOR USE IN THE TREATMENT OF CANCER | Nycomed GmbH (DE) | 2008-03-05 | — | — | EP | disclosed |
| WO-2006125815-A2 | TETRAHYDROPYRIDOTHIOPHENES FOR USE IN THE TREATMENT OF CANCER | NYCOMED GMBH (DE) | 2006-11-30 | — | — | WO | disclosed |
| WO-2006125813-A2 | TETRAHYDROPYRIDOTHIOPHENES FOR USE IN THE TREATMENT OF CANCER | NYCOMED GMBH (DE) | 2006-11-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090257977-A1 | NOVEL TETRAHYDROPYRIDOTHIOPHENES | BAX, BCL2, CCAR2 | KMT2A 2418/4885ALDH1A1 632/4885POLB 2460/4885 |
| US-20080260749-A1 | Novel Tetrahydropyridothiophenes | BAX, BCL2, CCAR2 | KMT2A 2644/4885ALDH1A1 615/4885POLB 2674/4885 |
| US-20080206258-A1 | Novel Tetrahydropyridothiophenes | BAX, BCL2, CCAR2 | KMT2A 2644/4885ALDH1A1 615/4885POLB 2674/4885 |
| US-20090258873-A1 | Novel tetrahydropyridothiophenes | BAX, BCL2, CCAR2 | KMT2A 2418/4885ALDH1A1 632/4885POLB 2460/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.