Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | VKORC1 | Q9BQB6 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | PGR | P06401 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
| ▸ | PDE4A | P27815 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | SNCA | P37840 | 1/20 | 0.47 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.47 |
| ▸ | BACE1 | P56817 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11858039 | 0.88 | KMT2A (0.48) | KMT2AVKORC1MAPTMEN1CYP3A4 | |
| SCHEMBL11858048 | 0.88 | KMT2A (0.48) | KMT2AVKORC1MAPTMEN1CYP3A4 | |
| SCHEMBL14767618 | 0.88 | KMT2A (0.48) | KMT2AVKORC1MAPTMEN1CYP3A4 | |
| SCHEMBL14768425 | 0.88 | KMT2A (0.48) | KMT2AVKORC1MAPTMEN1CYP3A4 | |
| SCHEMBL4322455 | 0.83 | TAAR1 (0.42) | KMT2AMAPTPTGS1MEN1ALDH1A1 | |
| SCHEMBL1414806 | 0.82 | DPP4 (0.48) | KMT2AVKORC1MAPTPGRHTR1A | |
| Farnesol SCHEMBL2206101 | 0.74 | KMT2A (0.56) | KMT2AMAPTPGRHTR1AADORA3 | |
| Geranylgeraniol SCHEMBL2291437 | 0.74 | KMT2A (0.56) | KMT2AMAPTPGRHTR1AADORA3 | |
| SCHEMBL17867387 | 0.73 | KMT2A (0.55) | KMT2AVKORC1MAPTPGRHTR1A | |
| SCHEMBL29939776 | 0.73 | TAAR1 (0.50) | MAPTPTGS1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160326212-A1 | Chemical Modification of Proteins | R.P. SCHERER TECHNOLOGIES, LLC | 2016-11-10 | — | — | US | disclosed |
| US-9346851-B2 | Chemical modification of proteins | R.P. SCHERER TECHNOLOGIES, LLC (US) | 2016-05-24 | — | — | US | disclosed |
| CN-101405401-B | Genetic programming expression of protein containing unnatural amino acid phenylselenocysteine | SCRIPPS RESEARCH INST | 2013-03-27 | — | — | CN | disclosed |
| EP-2254900-B1 | CHEMICAL MODIFICATION OF PROTEINS | ISIS INNOVATION (GB) | 2012-03-14 | — | — | EP | disclosed |
| US-20110144304-A1 | Chemical Modification of Proteins | REDWOOD BIOSCIENCE, INC. | 2011-06-16 | — | — | US | disclosed |
| EP-2254900-A1 | CHEMICAL MODIFICATION OF PROTEINS | ISIS Innovation Limited (GB) | 2010-12-01 | — | — | EP | disclosed |
| US-20100222546-A1 | METHODS FOR THE PREPARATION OF FUNCTIONALIZED PEPTIDES, PROTEINS AND CARBOHYDRATES AND THEIR CONJUGATES | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-09-02 | — | — | US | disclosed |
| WO-2009103941-A1 | CHEMICAL MODIFICATION OF PROTEINS | ISIS INNOVATION LIMITED (GB) | 2009-08-27 | — | — | WO | disclosed |
| CN-101405401-A | Genetic programming expression of protein containing unnatural amino acid phenylselenocysteine | SCRIPPS RESEARCH INST (US) | 2009-04-08 | — | — | CN | disclosed |
| WO-2008066816-A2 | DERIVATIZATION OR LIGATON OF PEPTIDES | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2008-06-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110144304-A1 | Chemical Modification of Proteins | SCLY, PTMS, QPCT | KMT2A 2362/4885VKORC1 2204/4885MAPT 3827/4885 |
| US-20160326212-A1 | Chemical Modification of Proteins | SCLY, PTMS, QPCT | KMT2A 2362/4885VKORC1 2204/4885MAPT 3827/4885 |
| US-20100222546-A1 | METHODS FOR THE PREPARATION OF FUNCTIONALIZED PEPTIDES, PROTEINS AND CARBOHYDRATES AND THEIR CONJUGATES | PTMS, STT3A, GCG | KMT2A 3803/4885VKORC1 3406/4885MAPT 1864/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.