SCHEMBL29628660

SCHEMBL29628660

COC(=O)CC(C)C(=O)c1cc(C)c(OC)c(F)c1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TAS1R3 Q7RTX0 3/20 0.40
TAS1R1 Q7RTX1 3/20 0.40
ALDH1A1 P00352 3/20 0.38
TUBB1 Q9H4B7 5/20 0.36
TUBB4A P04350 1/20 0.36
TUBB P07437 1/20 0.36
TUBA3C P0DPH7 1/20 0.36
TUBA1B P68363 1/20 0.36
TUBA4A P68366 1/20 0.36
TUBB4B P68371 1/20 0.36
TUBB3 Q13509 1/20 0.36
TUBB2A Q13885 1/20 0.36
TUBB8 Q3ZCM7 1/20 0.36
TUBA3E Q6PEY2 1/20 0.36
TUBA1A Q71U36 1/20 0.36
TUBA1C Q9BQE3 1/20 0.36
TUBB6 Q9BUF5 1/20 0.36
TUBB2B Q9BVA1 1/20 0.36
MAPT P10636 2/20 0.34
HTT P42858 2/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20607085 1.00 TAS1R3 (0.40) TAS1R3TAS1R1ALDH1A1TUBB1TUBB4A
SCHEMBL20607111 0.92 TUBB1 (0.39) TAS1R3TAS1R1ALDH1A1TUBB1MAPT
SCHEMBL20607391 0.85 ALDH1A1 (0.44) TAS1R3TAS1R1ALDH1A1TUBB1MAPT
SCHEMBL29628750 0.85 ALDH1A1 (0.44) TAS1R3TAS1R1ALDH1A1TUBB1MAPT
SCHEMBL20607078 0.82 TAS1R3 (0.32) TAS1R3TAS1R1
SCHEMBL29628825 0.82 TAS1R3 (0.32) TAS1R3TAS1R1
SCHEMBL13452128 0.81 HDAC1 (0.49) ALDH1A1MAPTHTTMEN1KMT2A
SCHEMBL20607067 0.80 PTPN1 (0.36) TAS1R3TAS1R1ALDH1A1TUBB1TUBB4A
SCHEMBL13304072 0.77 HTT (0.55) TAS1R3TAS1R1ALDH1A1MAPTHTT
SCHEMBL20607156 0.76 SMN1; SMN2 (0.33) ALDH1A1MAPTMEN1KMT2ARAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108779076-B 5-methyl-6-phenyl-4, 5-dihydro-2H-pyridazin-3-one derivatives 大塚制药株式会社 2022-05-03 CN disclosed