Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.49 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.49 |
| ▸ | HCRTR1 | O43613 | 14/20 | 0.47 |
| ▸ | HCRTR2 | O43614 | 10/20 | 0.47 |
| ▸ | DHODH | Q02127 | 1/20 | 0.45 |
| ▸ | KMO | O15229 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | DHFR | P00374 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TTR | P02766 | 1/20 | 0.43 |
| ▸ | ALB | P02768 | 1/20 | 0.43 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1586918 | 1.00 | KEAP1 (0.49) | KEAP1NAPRTHCRTR1HCRTR2DHODH | |
| SCHEMBL1586269 | 0.86 | NAPRT (0.49) | KEAP1NAPRTHCRTR1HCRTR2DHODH | |
| SCHEMBL17584502 | 0.86 | KEAP1 (0.49) | KEAP1HCRTR1HCRTR2DHODHKMO | |
| SCHEMBL15836281 | 0.85 | HCRTR1 (0.49) | HCRTR1HCRTR2 | |
| SCHEMBL16666096 | 0.85 | LMNA (0.47) | HCRTR1HCRTR2LMNA | |
| SCHEMBL19486956 | 0.83 | TTR (0.40) | HCRTR1HCRTR2DHODHKDM4EMEN1 | |
| SCHEMBL19902928 | 0.83 | HCRTR1 (0.42) | HCRTR1HCRTR2 | |
| SCHEMBL31585796 | 0.82 | HCRTR1 (0.50) | KEAP1NAPRTHCRTR1HCRTR2DHODH | |
| SCHEMBL11897021 | 0.82 | HCRTR1 (0.50) | KEAP1NAPRTHCRTR1HCRTR2DHODH | |
| SCHEMBL22190040 | 0.81 | KEAP1 (0.63) | KEAP1KMOKDM4EMEN1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4688155-A1 | MORPHOLINE OREXIN RECEPTOR ANTAGONISTS | Bial-Portela & CA, S.A. (PT) | 2026-02-11 | — | — | EP | disclosed |
| WO-2025023852-A1 | MORPHOLINE OREXIN RECEPTOR ANTAGONISTS | BIAL - PORTELA & CA., S.A. (PT) | 2025-01-30 | — | — | WO | disclosed |
| US-11324724-B2 | N-(2,2-difluoroethyl)-N-[(pyrimidinylamino)propanyl]arylcarboxamides | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2022-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11324724-B2 | N-(2,2-difluoroethyl)-N-[(pyrimidinylamino)propanyl]arylcarboxamides | HCRTR2, HCRTR1, CNR2 | KEAP1 785/4885NAPRT 512/4885HCRTR1 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.