SCHEMBL29628834

SCHEMBL29628834

O=[N+]([O-])c1cc(I)ccc1F

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.62
HIF1A Q16665 1/20 0.62
VCAM1 P19320 1/20 0.58
ATM Q13315 1/20 0.48
TDP1 Q9NUW8 1/20 0.48
LMNA P02545 7/20 0.45
HTT P42858 4/20 0.45
MAPT P10636 4/20 0.45
MEN1 O00255 3/20 0.45
KMT2A Q03164 3/20 0.45
GAA P10253 2/20 0.45
MITF O75030 1/20 0.45
NPSR1 Q6W5P4 1/20 0.45
CA1 P00915 1/20 0.45
MMP2 P08253 1/20 0.45
CA14 Q9ULX7 1/20 0.45
SMN1; SMN2 Q16637 1/20 0.45
AKR1C2 P52895 1/20 0.40
AKR1C1 Q04828 1/20 0.40
ESPL1 Q14674 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1476705 1.00 ALDH1A1 (0.62) ALDH1A1HIF1AVCAM1ATMTDP1
SCHEMBL18397203 0.83 TDP1 (0.64) ALDH1A1HIF1AVCAM1ATMTDP1
SCHEMBL31241209 0.83 TDP1 (0.64) ALDH1A1HIF1AVCAM1ATMTDP1
SCHEMBL6840900 0.80 TSHR (0.56) ALDH1A1HIF1AATMTDP1LMNA
SCHEMBL14371934 0.78 MAPT (0.43) ALDH1A1HIF1AATMTDP1MAPT
SCHEMBL1665978 0.78 PARP1 (0.56) ALDH1A1ATMTDP1LMNAHTT
SCHEMBL29462663 0.78 ATM (0.69) ALDH1A1HIF1AVCAM1ATMTDP1
SCHEMBL11579276 0.78 ALDH1A1 (0.67) ALDH1A1HIF1AVCAM1ATMTDP1
SCHEMBL102780 0.78 ATM (0.69) ALDH1A1HIF1AVCAM1ATMTDP1
SCHEMBL35276 0.77 ALDH1A1 (1.00) ALDH1A1HIF1AVCAM1ATMTDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4433484-A1 MACROCYCLIC 2-AMINO-BUT-3-ENAMIDES AS INHIBITORS OF MCL-1 JANSSEN Pharmaceutica NV (BE) 2024-09-25 EP disclosed
EP-4263558-A1 MACROCYCLIC BRANCHED 3-FLUORO-BUT-3-ENAMIDES AS INHIBITORS OF MCL-1 JANSSEN Pharmaceutica NV (BE) 2023-10-25 EP disclosed
WO-2023088894-A1 MACROCYCLIC 2-AMINO-BUT-3-ENAMIDES AS INHIBITORS OF MCL-1 JANSSEN PHARMACEUTICA NV (BE) 2023-05-25 WO disclosed
EP-4165050-A1 MACROCYCLIC 2-AMINO-3-FLUORO-BUT-3-ENAMIDES AS INHIBITORS OF MCL-1 JANSSEN Pharmaceutica NV (BE) 2023-04-19 EP disclosed
WO-2022261352-A1 PERFLUOROALKANE SUBSTITUTED PYRAZOLO[3,4-D]PYRIMIDIN AND PYRROLO[2,3-D]PYRIMIDIN COMPOUNDS AND USES THEREOF ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) 2022-12-15 WO disclosed
WO-2022237813-A1 COMPOUND HAVING ALK INHIBITORY ACTIVITY, PREPARATION METHOD THEREFOR AND USE THEREOF 盛世泰科生物医药技术(苏州)有限公司 2022-11-17 WO disclosed
WO-2022129331-A1 MACROCYCLIC BRANCHED 3-FLUORO-BUT-3-ENAMIDES AS INHIBITORS OF MCL-1 JANSSEN PHARMACEUTICA NV (BE) 2022-06-23 WO disclosed
EP-3997097-A1 MACROCYCLIC SPIROCYCLE DERIVATIVES AS MCL-1 INHIBITORS Janssen Pharmaceutica NV (BE) 2022-05-18 EP disclosed