SCHEMBL29630396

SCHEMBL29630396

Cc1nc(C=O)cc2c1[nH]c1ccccc12

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 5/20 0.56
KDM4E B2RXH2 3/20 0.56
ALDH1A1 P00352 2/20 0.56
HPGD P15428 2/20 0.56
MAPK1 P28482 2/20 0.56
HSD17B10 Q99714 2/20 0.56
LMNA P02545 2/20 0.56
TP53 P04637 1/20 0.56
MEN1 O00255 5/20 0.50
KMT2A Q03164 5/20 0.50
CYP1A2 P05177 2/20 0.50
GABRP O00591 1/20 0.50
GABRD O14764 1/20 0.50
CYP3A4 P08684 1/20 0.50
CYP2D6 P10635 1/20 0.50
GABRA1 P14867 1/20 0.50
TSHR P16473 1/20 0.50
GABRB1 P18505 1/20 0.50
GABRG2 P18507 1/20 0.50
NFKB1 P19838 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16892186 1.00 MAPT (0.56) MAPTKDM4EALDH1A1HPGDMAPK1
SCHEMBL18214992 0.85 MAPT (0.52) MAPTKDM4EALDH1A1HPGDMAPK1
SCHEMBL27979743 0.81 MAPT (0.46) MAPTKDM4EALDH1A1HPGDMAPK1
SCHEMBL16892187 0.81 MAPT (0.55) MAPTKDM4EALDH1A1HPGDMAPK1
SCHEMBL27908734 0.79 MEN1 (0.56) MAPTKDM4EALDH1A1HPGDHSD17B10
SCHEMBL29756559 0.79 DYRK1A (0.60) MAPTKDM4EALDH1A1HPGDMAPK1
SCHEMBL10169901 0.79 DYRK1A (0.60) MAPTKDM4EALDH1A1HPGDMAPK1
SCHEMBL9313465 0.76 MAPT (0.56) MAPTKDM4EALDH1A1HPGDMAPK1
SCHEMBL28667621 0.76 MAPT (0.56) MAPTKDM4EALDH1A1HPGDMAPK1
SCHEMBL10708983 0.76 MAPT (0.59) MAPTKDM4EALDH1A1HPGDMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3459950-B1 TETRAHYDRO-BETA-CARBOLINE ALKALOID DERIVATIVES, METHOD FOR PREPARING THE SAME AND USE IN ASPECTS OF PREVENTING AND TREATING PLANT VIRUSES, AS FUNGICIDES AND INSECTICIDES JINGBO AGROCHEMICALS TECH CO LTD (CN) 2022-05-18 EP disclosed
EP-3459951-B1 TETRAHYDRO-BETA-CARBOLINE ALKALOID DERIVATIVES, METHOD FOR PREPARING THE SAME AND USE IN ASPECTS OF PREVENTING AND TREATING PLANT VIRUSES, AS FUNGICIDES AND INSECTICIDES JINGBO AGROCHEMICALS TECH CO LTD (CN) 2022-05-11 EP disclosed