Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 5/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | GABRP | O00591 | 1/20 | 0.50 |
| ▸ | GABRD | O14764 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.50 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29630396 | 1.00 | MAPT (0.56) | MAPTKDM4EALDH1A1HPGDMAPK1 | |
| SCHEMBL18214992 | 0.85 | MAPT (0.52) | MAPTKDM4EALDH1A1HPGDMAPK1 | |
| SCHEMBL27979743 | 0.81 | MAPT (0.46) | MAPTKDM4EALDH1A1HPGDMAPK1 | |
| SCHEMBL16892187 | 0.81 | MAPT (0.55) | MAPTKDM4EALDH1A1HPGDMAPK1 | |
| SCHEMBL27908734 | 0.79 | MEN1 (0.56) | MAPTKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL29756559 | 0.79 | DYRK1A (0.60) | MAPTKDM4EALDH1A1HPGDMAPK1 | |
| SCHEMBL10169901 | 0.79 | DYRK1A (0.60) | MAPTKDM4EALDH1A1HPGDMAPK1 | |
| SCHEMBL9313465 | 0.76 | MAPT (0.56) | MAPTKDM4EALDH1A1HPGDMAPK1 | |
| SCHEMBL28667621 | 0.76 | MAPT (0.56) | MAPTKDM4EALDH1A1HPGDMAPK1 | |
| SCHEMBL10708983 | 0.76 | MAPT (0.59) | MAPTKDM4EALDH1A1HPGDMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3459950-A1 | BETA-CARBOLINE, DIHYDRO-BETA-CARBOLINE AND TETRAHYDRO-BETA-CARBOLINE ALKALOID DERIVATIVES, METHOD FOR PREPARING THE SAME AND USE IN ASPECTS OF PREVENTING AND TREATING PLANT VIRUSES, AS FUNGICIDES AND INSECTICIDES | Nankai University (CN) | 2019-03-27 | — | — | EP | disclosed |
| US-10208033-B2 | β-carboline, dihydro-β-carboline and tetrahydro-β-carboline alkaloid derivatives and preparation methods same and use in aspects of preventing and treating plant viruses, fungicides and insecticides | NANKAI UNIVERSITY (CN) | 2019-02-19 | — | — | US | disclosed |
| EP-3091015-B1 | BETA-CARBOLINE, DIHYDRO-BETA-CARBOLINE AND TETRAHYDRO-BETA-CARBOLINE ALKALOID DERIVATIVES AND METHOD FOR PREPARING SAME AND USE IN ASPECTS OF PREVENTING AND TREATING PLANT VIRUSES, FUNGICIDES AND INSECTICIDES | UNIV NANKAI (CN) | 2019-02-13 | — | — | EP | disclosed |
| US-20160326166-A1 | ß-CARBOLINE, DIHYDRO-ß-CARBOLINE AND TETRAHYDRO-ß-CARBOLINE ALKALOID DERIVATIVES AND PREPARATION METHODS SAME AND USE IN ASPECTS OF PREVENTING AND TREATING PLANT VIRUSES, FUNGICIDES AND INSECTICIDES | NANKAI UNIVERSITY (CN) | 2016-11-10 | — | — | US | disclosed |
| US-20160326166-A1 | ß-CARBOLINE, DIHYDRO-ß-CARBOLINE AND TETRAHYDRO-ß-CARBOLINE ALKALOID DERIVATIVES AND PREPARATION METHODS SAME AND USE IN ASPECTS OF PREVENTING AND TREATING PLANT VIRUSES, FUNGICIDES AND INSECTICIDES | NANKAI UNIVERSITY (CN) | 2016-11-10 | — | — | US | disclosed |
| US-20160326166-A1 | ß-CARBOLINE, DIHYDRO-ß-CARBOLINE AND TETRAHYDRO-ß-CARBOLINE ALKALOID DERIVATIVES AND PREPARATION METHODS SAME AND USE IN ASPECTS OF PREVENTING AND TREATING PLANT VIRUSES, FUNGICIDES AND INSECTICIDES | NANKAI UNIVERSITY (CN) | 2016-11-10 | — | — | US | disclosed |
| WO-2015101206-A1 | Β-CARBOLINE, DIHYDRO-Β-CARBOLINE AND TETRAHYDRO-Β-CARBOLINE ALKALOID DERIVATIVES AND METHOD FOR PREPARING SAME AND USE IN ASPECTS OF PREVENTING AND TREATING PLANT VIRUSES, FUNGICIDES AND INSECTICIDES | 南开大学 | 2015-07-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160326166-A1 | ß-CARBOLINE, DIHYDRO-ß-CARBOLINE AND TETRAHYDRO-ß-CARBOLINE ALKALOID DERIVATIVES AND PREPARATION METHODS SAME AND USE IN ASPECTS OF PREVENTING AND TREATING PLANT VIRUSES, FUNGICIDES AND INSECTICIDES | DDT, NOTUM, DDAH1 | MAPT 1698/4885KDM4E 1695/4885ALDH1A1 340/4885 |
| US-10208033-B2 | β-carboline, dihydro-β-carboline and tetrahydro-β-carboline alkaloid derivatives and preparation methods same and use in aspects of preventing and treating plant viruses, fungicides and insecticides | DDT, ZC3HAV1, NOTUM | MAPT 1786/4885KDM4E 1731/4885ALDH1A1 389/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.