Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 20/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18131149 | 1.00 | NTRK1 (0.57) | NTRK1 | |
| SCHEMBL17111543 | 0.87 | NTRK1 (0.53) | NTRK1 | |
| SCHEMBL29633186 | 0.76 | NTRK1 (0.53) | NTRK1 | |
| SCHEMBL17110517 | 0.75 | NTRK1 (1.00) | NTRK1 | |
| SCHEMBL17129768 | 0.73 | NTRK1 (0.48) | NTRK1 | |
| SCHEMBL17111537 | 0.72 | JAK2 (0.46) | — | |
| SCHEMBL24065779 | 0.71 | NTRK1 (0.60) | NTRK1 | |
| SCHEMBL22093024 | 0.71 | DGAT1 (0.49) | — | |
| SCHEMBL31145404 | 0.71 | DGAT1 (0.49) | — | |
| SCHEMBL25357279 | 0.71 | SCN9A (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3122344-B1 | TRKA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF | MERCK SHARP & DOHME (US) | 2022-04-27 | — | — | EP | claimed |
| EP-3122344-B1 | TRKA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF | MERCK SHARP & DOHME (US) | 2022-04-27 | — | — | EP | disclosed |