Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 14/20 | 0.51 |
| ▸ | MAPK10 | P53779 | 9/20 | 0.51 |
| ▸ | RET | P07949 | 3/20 | 0.51 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.51 |
| ▸ | CDK1 | P06493 | 2/20 | 0.51 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.51 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.51 |
| ▸ | GSK3B | P49841 | 2/20 | 0.51 |
| ▸ | CDC7 | O00311 | 1/20 | 0.51 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.51 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.51 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.51 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.51 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.51 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.51 |
| ▸ | JAK2 | O60674 | 1/20 | 0.51 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.51 |
| ▸ | PAK4 | O96013 | 1/20 | 0.51 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24435934 | 1.00 | ERN1 (0.51) | ERN1MAPK10RETCCNB2CDK1 | |
| SCHEMBL29049062 | 0.89 | ERN1 (0.47) | ERN1MAPK10AURKB | |
| SCHEMBL29633613 | 0.84 | TEK (0.42) | ERN1MAPK10MAPK8MAPK9AURKB | |
| SCHEMBL24435876 | 0.84 | TEK (0.42) | ERN1MAPK10MAPK8MAPK9AURKB | |
| SCHEMBL24439288 | 0.83 | ERN1 (0.47) | ERN1MAPK10RETCCNB2CDK1 | |
| SCHEMBL24435785 | 0.81 | ERN1 (0.52) | ERN1MAPK10 | |
| SCHEMBL29633607 | 0.81 | ERN1 (0.52) | ERN1MAPK10 | |
| SCHEMBL24435821 | 0.81 | ERN1 (0.52) | ERN1MAPK10 | |
| SCHEMBL28557737 | 0.81 | ERN1 (0.43) | ERN1MAPK10CCNB2CDK1CCNB1 | |
| SCHEMBL24435930 | 0.80 | ERN1 (0.54) | ERN1MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4243815-A1 | IRE1ALPHA INHIBITORS AND USES THEREOF | The Regents of the University of California (US) | 2023-09-20 | — | — | EP | disclosed |
| WO-2022104151-A1 | IRE1ALPHA INHIBITORS AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2022-05-19 | — | — | WO | disclosed |