Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.67 |
| ▸ | CSNK2A2 | P19784 | 3/20 | 0.58 |
| ▸ | CSNK2B | P67870 | 3/20 | 0.58 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | HPGD | P15428 | 3/20 | 0.58 |
| ▸ | DNA2 | P51530 | 1/20 | 0.57 |
| ▸ | CASP6 | P55212 | 1/20 | 0.57 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.48 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.48 |
| ▸ | CLEC4M | Q9H2X3 | 1/20 | 0.44 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.43 |
| ▸ | WNT3A | P56704 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2660023 | 0.81 | CYP1A2 (0.57) | KDM4ECSNK2A2CSNK2BCSNK2A1ALDH1A1 | |
| SCHEMBL18589537 | 0.81 | CSNK2A2 (0.69) | KDM4ECSNK2A2CSNK2BCSNK2A1ALDH1A1 | |
| SCHEMBL4742144 | 0.80 | KDM4E (1.00) | KDM4EALDH1A1HPGDCYP1A2MEN1 | |
| SCHEMBL2976084 | 0.80 | CSNK2A2 (0.63) | KDM4ECSNK2A2CSNK2BCSNK2A1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL31157465 | 0.79 | CSNK2A2 (0.61) | KDM4ECSNK2A2CSNK2BCSNK2A1ALDH1A1 | |
| SCHEMBL1244916 | 0.78 | CSNK2A2 (0.65) | KDM4ECSNK2A2CSNK2BCSNK2A1ALDH1A1 | |
| SCHEMBL4339753 | 0.77 | CSNK2A2 (0.63) | KDM4ECSNK2A2CSNK2BCSNK2A1ALDH1A1 | |
| SCHEMBL2979929 | 0.77 | CSNK2A2 (0.69) | KDM4ECSNK2A2CSNK2BCSNK2A1ALDH1A1 | |
| SCHEMBL2977498 | 0.77 | KDM4E (0.67) | KDM4ECSNK2A2CSNK2BCSNK2A1ALDH1A1 | |
| SCHEMBL1353154 | 0.77 | CYP1A2 (0.51) | KDM4ECSNK2A2CSNK2BCSNK2A1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108409653-A | 8-（Trifluoromethyl）The synthetic method of quinoline-3-carboxylic acid | 苏州康润医药有限公司 | 2018-08-17 | — | — | CN | disclosed |
| US-20140343098-A1 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2014-11-20 | — | — | US | disclosed |
| US-8802700-B2 | Modulators of ATP-Binding Cassette transporters | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2014-08-12 | — | — | US | disclosed |
| US-8614327-B2 | Modulators of ATP-binding cassette transporters | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-12-24 | — | — | US | disclosed |
| US-20130165442-A1 | Modulators of ATP-Binding Cassette Transporters | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-06-27 | — | — | US | disclosed |
| US-8354427-B2 | Modulators of ATP-binding cassette transporters | VERTEX PHARMACEUTICAL INCORPORATED (US) | 2013-01-15 | — | — | US | disclosed |
| US-20120309758-A1 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-12-06 | — | — | US | disclosed |
| US-20100184739-A1 | Modulators of ATP-Binding Cassette Transporters | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-07-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130165442-A1 | Modulators of ATP-Binding Cassette Transporters | CFTR, ABCB1, ABCC2 | KDM4E 4262/4885CSNK2A2 4063/4885CSNK2B 3358/4885 |
| US-20100184739-A1 | Modulators of ATP-Binding Cassette Transporters | CFTR, ABCB1, ABCC2 | KDM4E 4262/4885CSNK2A2 4063/4885CSNK2B 3358/4885 |
| US-20140343098-A1 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | CFTR, ABCB1, ABCC2 | KDM4E 4262/4885CSNK2A2 4063/4885CSNK2B 3358/4885 |
| US-20120309758-A1 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | CFTR, ABCB1, ABCC2 | KDM4E 4262/4885CSNK2A2 4063/4885CSNK2B 3358/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.