SCHEMBL29634256

SCHEMBL29634256

COc1ccc2c(c1)OCC=C2

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
STS P08842 1/20 0.60
CA2 P00918 3/20 0.49
CA5A P35218 2/20 0.49
HTR2C P28335 1/20 0.46
ALOX5 P09917 1/20 0.43
NFKB1 P19838 1/20 0.41
NFKB2 Q00653 1/20 0.41
RELA Q04206 1/20 0.41
NR1H4 Q96RI1 1/20 0.40
TRPA1 O75762 1/20 0.40
CA12 O43570 3/20 0.38
CA9 Q16790 3/20 0.38
DRD2 P14416 1/20 0.37
DRD1 P21728 1/20 0.37
DRD4 P21917 1/20 0.37
DRD5 P21918 1/20 0.37
DRD3 P35462 1/20 0.37
KDM4E B2RXH2 2/20 0.36
CYP3A4 P08684 2/20 0.36
MAPT P10636 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28445528 1.00 STS (0.60) STSCA2CA5AHTR2CALOX5
SCHEMBL5229806 0.86 CA12 (0.49) STSCA2CA5AALOX5NR1H4
SCHEMBL30545230 0.86 CA12 (0.49) STSCA2CA5AALOX5NR1H4
SCHEMBL27397632 0.82 STS (0.60) STSCA2CA5AHTR2C
SCHEMBL18055910 0.78 ALOX5 (0.53) STSCA2CA5AHTR2CALOX5
SCHEMBL9825409 0.76 STS (0.54) STSCA12CA9CYP3A4MAPT
SCHEMBL9113863 0.76 STS (0.38) STSCA2CA5AALOX5CA12
SCHEMBL30421522 0.76 STS (0.53) STSCA2CA5AALOX5KDM4E
SCHEMBL31190208 0.76 STS (0.53) STSCA2CA5AALOX5ALDH1A1
SCHEMBL21365816 0.76 STS (0.50) STSALOX5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025007873-A1 KAT6 INHIBITOR 上海齐鲁制药研究中心有限公司 2025-01-09 WO disclosed
CN-112898278-B Preparation and application of Sigma-2 fluorescent ligand 广东医科大学 2022-05-13 CN disclosed