Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | PARG | Q86W56 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 3/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL349527 | 0.87 | MAPT (0.66) | MAPTSMN1; SMN2KMT2AMEN1LMNA | |
| Trifluoroacetic Acid SCHEMBL15918326 | 0.86 | GAA (0.56) | MAPTSMN1; SMN2KMT2AMEN1HPGD | |
| Boric Acid SCHEMBL5885888 | 0.84 | MAPT (0.58) | MAPTSMN1; SMN2KMT2AMEN1LMNA | |
| SCHEMBL4680184 | 0.84 | MAPT (0.58) | MAPTSMN1; SMN2KMT2AMEN1LMNA | |
| Trifluoroacetic Acid SCHEMBL2224180 | 0.82 | NR3C2 (0.54) | SMN1; SMN2KMT2ALMNANPC1HPGD | |
| Trifluoroacetic Acid SCHEMBL1805155 | 0.82 | NR3C2 (0.54) | SMN1; SMN2KMT2ALMNANPC1HPGD | |
| Trifluoroacetic Acid SCHEMBL27626580 | 0.80 | CA1 (0.50) | SMN1; SMN2KMT2AMEN1HPGDGAA | |
| SCHEMBL10402270 | 0.80 | BCAT1 (0.50) | MAPTSMN1; SMN2KMT2AMEN1LMNA | |
| Trifluoroacetic Acid SCHEMBL28039127 | 0.79 | NR3C2 (0.51) | SMN1; SMN2KMT2AMEN1LMNANPC1 | |
| Trifluoroacetic Acid SCHEMBL18429767 | 0.79 | CYP2C19 (0.59) | SMN1; SMN2KMT2AMEN1LMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108350062-B | Targeted protein degradation to attenuate adverse inflammatory responses associated with adoptive T cell therapy | 达纳-法伯癌症研究所股份有限公司 | 2022-10-14 | — | — | CN | disclosed |
| US-20220135967-A1 | TUNABLE ENDOGENOUS PROTEIN DEGRADATION | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2022-05-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220135967-A1 | TUNABLE ENDOGENOUS PROTEIN DEGRADATION | PSMG3, MYCBP, DBN1 | MAPT 3101/4885SMN1; SMN2 4262/4885KMT2A 2488/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.