Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.76 |
| ▸ | MEN1 | O00255 | 5/20 | 0.76 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.76 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.76 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.68 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.68 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.68 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.68 |
| ▸ | USP2 | O75604 | 1/20 | 0.67 |
| ▸ | THRB | P10828 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.64 |
| ▸ | MAPT | P10636 | 1/20 | 0.64 |
| ▸ | PKM | P14618 | 1/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.63 |
| ▸ | LMNA | P02545 | 2/20 | 0.63 |
| ▸ | POLB | P06746 | 1/20 | 0.63 |
| ▸ | NPC1 | O15118 | 2/20 | 0.62 |
| ▸ | RAB9A | P51151 | 2/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1116738 | 1.00 | KMT2A (0.76) | KMT2AMEN1CYP3A4CYP1A2CYP2C9 | |
| SCHEMBL5555262 | 0.91 | GAA (0.74) | KMT2AMEN1CYP3A4CYP1A2CYP2C9 | |
| SCHEMBL25328235 | 0.87 | THRB (0.77) | KMT2AMEN1CYP3A4CYP1A2CYP2C9 | |
| SCHEMBL4143110 | 0.87 | KMT2A (1.00) | KMT2AMEN1CYP3A4CYP1A2CYP2C9 | |
| SCHEMBL7892909 | 0.86 | KMT2A (0.67) | KMT2AMEN1CYP3A4CYP1A2CYP2C9 | |
| SCHEMBL19591887 | 0.85 | KMT2A (0.73) | KMT2AMEN1CYP3A4CYP1A2CYP2C9 | |
| SCHEMBL20254508 | 0.85 | KMT2A (0.69) | KMT2AMEN1CYP3A4CYP1A2CYP2C9 | |
| SCHEMBL16448998 | 0.85 | KMT2A (0.69) | KMT2AMEN1CYP3A4CYP1A2CYP2C9 | |
| SCHEMBL10886794 | 0.85 | HDAC1 (0.70) | KMT2AMEN1CYP3A4CYP1A2CYP2C9 | |
| SCHEMBL29447171 | 0.85 | USP2 (0.80) | KMT2AMEN1CYP3A4CYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107344936-B | Triazolopyridazine derivative, preparation method, pharmaceutical composition and application thereof | 上海赛默罗生物科技有限公司 | 2022-06-03 | — | — | CN | disclosed |