Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APLNR | P35414 | 1/20 | 0.52 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.51 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.51 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.51 |
| ▸ | MC4R | P32245 | 1/20 | 0.51 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.50 |
| ▸ | CTSL | P07711 | 3/20 | 0.49 |
| ▸ | CTSS | P25774 | 3/20 | 0.49 |
| ▸ | CTSK | P43235 | 3/20 | 0.49 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.49 |
| ▸ | CTSH | P09668 | 1/20 | 0.49 |
| ▸ | IL23R | Q5VWK5 | 1/20 | 0.49 |
| ▸ | CALCR | P30988 | 4/20 | 0.48 |
| ▸ | CALCRL | Q16602 | 2/20 | 0.48 |
| ▸ | GLP1R | P43220 | 1/20 | 0.48 |
| ▸ | GCGR | P47871 | 1/20 | 0.48 |
| ▸ | GIPR | P48546 | 1/20 | 0.48 |
| ▸ | NMUR2 | Q9GZQ4 | 1/20 | 0.48 |
| ▸ | NMUR1 | Q9HB89 | 1/20 | 0.48 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29675066 | 0.95 | MC4R (0.56) | APLNRMAPK8MAPK9MAPK10MC4R | |
| SCHEMBL30262190 | 0.90 | APLNR (0.53) | APLNRMAPK8MAPK9MAPK10MC4R | |
| SCHEMBL29634985 | 0.85 | CALCRL (0.57) | KEAP1CALCRLNMUR2NMUR1 | |
| SCHEMBL29934240 | 0.85 | APLNR (0.61) | APLNRMAPK8MAPK9MAPK10CTSL | |
| SCHEMBL30974054 | 0.85 | CALCRL (0.56) | APLNRMAPK8MAPK9MAPK10CTSL | |
| SCHEMBL30974445 | 0.84 | CALCRL (0.55) | APLNRMAPK8MAPK9MAPK10CTSL | |
| SCHEMBL31386983 | 0.84 | C5AR1 (0.58) | MC4RKEAP1IL23RCALCR | |
| SCHEMBL30974077 | 0.83 | EPHA2 (0.57) | APLNRCTSLCTSSCTSKKEAP1 | |
| SCHEMBL30231309 | 0.83 | APLNR (0.62) | APLNRMAPK8MAPK9MAPK10CTSL | |
| SCHEMBL29506916 | 0.83 | APLNR (0.52) | APLNRMAPK8MAPK9MAPK10SLC40A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3997104-A1 | COMPOUNDS COMPRISING A FIBROBLAST ACTIVATION PROTEIN LIGAND AND USE THEREOF | 3B Pharmaceuticals GmbH (DE) | 2022-05-18 | — | — | EP | disclosed |