Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | ATR | Q13535 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.33 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.33 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.33 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.33 |
| ▸ | CSF1R | P07333 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 4/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23015098 | 1.00 | ELANE (0.42) | ELANETDP1GRM2KDM1AMAPK1 | |
| SCHEMBL23015298 | 0.81 | SIGMAR1 (0.40) | KDM4EALDH1A1 | |
| SCHEMBL29874793 | 0.81 | SIGMAR1 (0.40) | KDM4EALDH1A1 | |
| SCHEMBL29636738 | 0.74 | SLC2A1 (0.51) | ACHE | |
| SCHEMBL23015129 | 0.74 | SLC2A1 (0.51) | ACHE | |
| SCHEMBL29219443 | 0.74 | ELANE (0.49) | ELANETDP1GRM2KDM1AMAPK1 | |
| SCHEMBL28967175 | 0.72 | KDM4E (0.52) | TDP1MAPK1KDM4EALDH1A1L3MBTL1 | |
| SCHEMBL29636671 | 0.72 | KDM4E (0.52) | TDP1MAPK1KDM4EALDH1A1L3MBTL1 | |
| SCHEMBL23015344 | 0.71 | GRM2 (0.46) | GRM2KDM1AMAPK1KDM4EALDH1A1 | |
| SCHEMBL29636726 | 0.71 | GRM2 (0.46) | GRM2KDM1AMAPK1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4017492-A1 | MOLECULES THAT BIND TO TDP-43 FOR THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS AND RELATED DISORDERS | Biohaven Therapeutics Ltd. (US) | 2022-06-29 | — | — | EP | claimed |