Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.52 |
| ▸ | POLB | P06746 | 9/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 7/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 7/20 | 0.52 |
| ▸ | GLA | P06280 | 4/20 | 0.52 |
| ▸ | HPGD | P15428 | 4/20 | 0.52 |
| ▸ | GAA | P10253 | 3/20 | 0.52 |
| ▸ | ESR1 | P03372 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | RECQL | P46063 | 6/20 | 0.48 |
| ▸ | MAPT | P10636 | 6/20 | 0.48 |
| ▸ | MEN1 | O00255 | 5/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.45 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.45 |
| ▸ | CTDSP1 | Q9GZU7 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28967175 | 1.00 | KDM4E (0.52) | KDM4EPOLBALDH1A1TDP1L3MBTL1 | |
| SCHEMBL23234949 | 0.75 | KDM4E (0.62) | KDM4EPOLBALDH1A1TDP1L3MBTL1 | |
| SCHEMBL27795966 | 0.74 | KDM4E (0.61) | KDM4EPOLBALDH1A1TDP1L3MBTL1 | |
| SCHEMBL28967193 | 0.72 | ALDH1A1 (0.59) | KDM4EALDH1A1HPGDMAPK1HSD17B10 | |
| SCHEMBL23015082 | 0.72 | ACP1 (0.68) | KDM4EPOLBALDH1A1TDP1L3MBTL1 | |
| SCHEMBL29636675 | 0.72 | ACP1 (0.68) | KDM4EPOLBALDH1A1TDP1L3MBTL1 | |
| SCHEMBL12203776 | 0.72 | KDM4E (0.62) | KDM4EPOLBALDH1A1TDP1L3MBTL1 | |
| SCHEMBL23015098 | 0.72 | ELANE (0.42) | KDM4EALDH1A1TDP1L3MBTL1MAPK1 | |
| SCHEMBL29636665 | 0.72 | ELANE (0.42) | KDM4EALDH1A1TDP1L3MBTL1MAPK1 | |
| Hydrochloric Acid SCHEMBL29636779 | 0.72 | ALDH1A1 (0.57) | KDM4EALDH1A1HPGDMAPK1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4017492-A1 | MOLECULES THAT BIND TO TDP-43 FOR THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS AND RELATED DISORDERS | Biohaven Therapeutics Ltd. (US) | 2022-06-29 | — | — | EP | claimed |