Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | LMNA | P02545 | 4/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | GBA1 | P04062 | 2/20 | 0.51 |
| ▸ | DHODH | Q02127 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.48 |
| ▸ | CCNK | O75909 | 1/20 | 0.48 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.48 |
| ▸ | CDK2 | P24941 | 1/20 | 0.48 |
| ▸ | CCND3 | P30281 | 1/20 | 0.48 |
| ▸ | CDK9 | P50750 | 1/20 | 0.48 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | JAK3 | P52333 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23015108 | 1.00 | ALDH1A1 (0.53) | ALDH1A1LMNAKDM4EGAAGBA1 | |
| SCHEMBL23015375 | 0.87 | MAPT (0.46) | ALDH1A1LMNAKDM4EGAADHODH | |
| SCHEMBL29636799 | 0.87 | MAPT (0.46) | ALDH1A1LMNAKDM4EGAADHODH | |
| SCHEMBL23015150 | 0.85 | SUV39H2 (0.51) | ALDH1A1KDM4ENPSR1HPGDALK | |
| SCHEMBL19989884 | 0.83 | CKS1B (0.55) | ALDH1A1KDM4EGBA1HPGDGPR119 | |
| SCHEMBL26967706 | 0.82 | MAPT (0.46) | ALDH1A1LMNAGBA1NPSR1GPR119 | |
| SCHEMBL20768795 | 0.81 | SMYD3 (0.73) | ALDH1A1GBA1SMYD3HPGDGPR119 | |
| SCHEMBL23015253 | 0.80 | SMYD3 (0.39) | GBA1DHODHSMYD3HPGDGPR119 | |
| SCHEMBL29636838 | 0.80 | SMYD3 (0.39) | GBA1DHODHSMYD3HPGDGPR119 | |
| SCHEMBL23015131 | 0.79 | SLC2A1 (0.51) | ALDH1A1LMNAKDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4017492-A1 | MOLECULES THAT BIND TO TDP-43 FOR THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS AND RELATED DISORDERS | Biohaven Therapeutics Ltd. (US) | 2022-06-29 | — | — | EP | disclosed |