Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.35 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.33 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.30 |
| ▸ | KCNN3 | Q9UGI6 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29638115 | 0.84 | ALDH1A1 (0.35) | EGFRGAAL3MBTL1ALDH1A1SMN1; SMN2 | |
| SCHEMBL29638105 | 0.83 | ALDH1A1 (0.34) | EGFRGAAALDH1A1SMN1; SMN2 | |
| SCHEMBL29638120 | 0.82 | EGFR (0.44) | EGFR | |
| SCHEMBL29638104 | 0.73 | MAPKAPK2 (0.45) | EGFRMAPTSMN1; SMN2 | |
| SCHEMBL29597402 | 0.63 | KMT2A (0.47) | EGFRLMNAMEN1MAPTKMT2A | |
| SCHEMBL31588399 | 0.63 | SCN9A (0.43) | MEN1MAPTKMT2AGAAPOLB | |
| SCHEMBL30948589 | 0.62 | CCNT1 (0.42) | EGFRLMNAMEN1MAPTKMT2A | |
| SCHEMBL19239593 | 0.61 | ALDH1A1 (0.42) | MEN1MAPTKMT2AGAAL3MBTL1 | |
| SCHEMBL32681522 | 0.60 | CCNT1 (0.42) | EGFRLMNAMEN1MAPTKMT2A | |
| SCHEMBL30040910 | 0.60 | KMT2A (0.41) | EGFRLMNAMEN1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110950871-B | 2-substituted-4-arylamino pyrazolotriazine derivative and application thereof in preparing antitumor drugs | 陕西师范大学 | 2022-05-17 | — | — | CN | claimed |
| CN-110950871-B | 2-substituted-4-arylamino pyrazolotriazine derivative and application thereof in preparing antitumor drugs | 陕西师范大学 | 2022-05-17 | — | — | CN | disclosed |